estimated.TSHI: Jostels TSH index (TSHI of JTI)

In SPINA: Structure Parameter Inference Approach

Description

Calculate Jostels TSH index (also referred to as TSHI or JTI) from equilibrium TSH and free T4 concentrations.

Usage

estimated.TSHI(TSH, FT4)

Arguments

TSH	Thyrotropin (TSH) concentration in mIU/l
FT4	Free thyroxine (FT4) concentration in pmol/L

Details

This function is able to do vectorised calculations.

Value

This function returns Jostel's TSH index as a numeric result representing a single value or a vector, depending on the vector length of the arguments. Results are without unit of measurement.

Note

The software functions described in this document are intended for research use only. Hormone levels should have been obtained simultaneously in order to avoid bias by transition effects.

Author(s)

Johannes W. Dietrich

References

Jostel A, Ryder WD, Shalet SM. The use of thyroid function tests in the diagnosis of hypopituitarism: definition and evaluation of the TSH Index. Clin Endocrinol (Oxf). 2009 Oct;71(4):529-34. doi: 10.1111/j.1365-2265.2009.03534.x. PMID: 19226261.

Dietrich J. W., Landgrafe G., Fotiadou E. H. 2012 TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis. J Thyroid Res. 2012;2012:351864. doi: 10.1155/2012/351864. PMID: 23365787; PMCID: PMC3544290.

Dietrich J. W., Landgrafe-Mende G., Wiora E., Chatzitomaris A., Klein H. H., Midgley J. E., Hoermann R. 2016 Calculated Parameters of Thyroid Homeostasis: Emerging Tools for Differential Diagnosis and Clinical Research. Front Endocrinol (Lausanne). 2016 Jun 9;7:57. doi: 10.3389/fendo.2016.00057. PMID: 27375554; PMCID: PMC4899439.

See Also

SPINA.GT, estimated.GT, SPINA.GTT, estimated.GTT, SPINA.GD, estimated.GD, SPINA.GDTT, estimated.GDTT, SPINA.sGD, estimated.sGD, estimated.sTSHI, estimated.TTSI

Examples

TSH <- c(1, 3.24, 0.7);
FT4 <- c(16.5, 7.7, 9);
FT3 <- c(4.5, 28, 6.2);
print(paste("GT^:", SPINA.GT(TSH, FT4)));
print(paste("GD^:", SPINA.GD(FT4, FT3)));
print(paste("sGD^:", SPINA.sGD(FT4, FT3)));

Example output

[1] "GT^: 4.696993125"      "GT^: 1.08063057191358" "GT^: 3.36719507142857"
[1] "GD^: 25.2176153706294" "GD^: 336.22895406993"  "GD^: 63.6968730188034"
[1] "sGD^: -0.956476925874126" "sGD^: 61.245790813986"   
[3] "sGD^: 6.73937460376069"  

SPINA documentation built on May 2, 2019, 3:41 p.m.