estimated.TTSI: Thyrotroph Thyroid Hormone Sensitivity Index (TTSI)

In SPINA: Structure Parameter Inference Approach

Description

Calculate thyrotroph thyroid hormone sensitivity index (TTSI) from equilibrium TSH and free T4 concentrations.

Usage

estimated.TTSI(TSH, FT4, lu)

Arguments

TSH	Thyrotropin (TSH) concentration in mIU/l
FT4	Free thyroxine (FT4) concentration in pmol/L
lu	upper limit of FT4 reference range (should be in the same unit of measurement as the FT4 concentration)

Details

This function is able to do vectorised calculations.

Value

This function returns thyrotroph thyroid hormone sensitivity index (TTSI) as a numeric result representing a single value or a vector, depending on the vector length of the arguments. Results are without unit of measurement.

Note

The software functions described in this document are intended for research use only. Hormone levels should have been obtained simultaneously in order to avoid bias by transition effects.

Author(s)

Johannes W. Dietrich

References

Pohlenz J, Weiss RE, Macchia PE, Pannain S, Lau IT, Ho H, Refetoff S. Five new families with resistance to thyroid hormone not caused by mutations in the thyroid hormone receptor beta gene. J Clin Endocrinol Metab. 1999 Nov;84(11):3919-28. PMID: 10566629.

Dietrich J. W., Landgrafe G., Fotiadou E. H. 2012 TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis. J Thyroid Res. 2012;2012:351864. doi: 10.1155/2012/351864. PMID: 23365787; PMCID: PMC3544290.

Dietrich J. W., Landgrafe-Mende G., Wiora E., Chatzitomaris A., Klein H. H., Midgley J. E., Hoermann R. 2016 Calculated Parameters of Thyroid Homeostasis: Emerging Tools for Differential Diagnosis and Clinical Research. Front Endocrinol (Lausanne). 2016 Jun 9;7:57. doi: 10.3389/fendo.2016.00057. PMID: 27375554; PMCID: PMC4899439.

See Also

SPINA.GT, estimated.GT, SPINA.GTT, estimated.GTT, SPINA.GD, estimated.GD, SPINA.GDTT, estimated.GDTT, SPINA.sGD, estimated.sGD, estimated.TSHI, estimated.sTSHI

Examples

TSH <- c(1, 3.24, 0.7);
FT4 <- c(16.5, 7.7, 9);
FT3 <- c(4.5, 28, 6.2);
print(paste("GT^:", SPINA.GT(TSH, FT4)));
print(paste("GD^:", SPINA.GD(FT4, FT3)));
print(paste("sGD^:", SPINA.sGD(FT4, FT3)));

Example output

[1] "GT^: 4.696993125"      "GT^: 1.08063057191358" "GT^: 3.36719507142857"
[1] "GD^: 25.2176153706294" "GD^: 336.22895406993"  "GD^: 63.6968730188034"
[1] "sGD^: -0.956476925874126" "sGD^: 61.245790813986"   
[3] "sGD^: 6.73937460376069"  

SPINA documentation built on May 2, 2019, 3:41 p.m.