SeqKat: Detection of Kataegis

Kataegis is a localized hypermutation occurring when a region is enriched in somatic SNVs. Kataegis can result from multiple cytosine deaminations catalyzed by the AID/APOBEC family of proteins. This package contains functions to detect kataegis from SNVs in BED format. This package reports two scores per kataegic event, a hypermutation score and an APOBEC mediated kataegic score. Yousif, F. et al.; The Origins and Consequences of Localized and Global Somatic Hypermutation; Biorxiv 2018 <doi:10.1101/287839>.

Package details

AuthorFouad Yousif, Xihui Lin, Fan Fan, Christopher Lalansingh, John Macdonald
MaintainerPaul C. Boutros <>
Package repositoryView on CRAN
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SeqKat documentation built on March 13, 2020, 1:59 a.m.