Kataegis is a localized hypermutation occurring when a region is enriched in somatic SNVs. Kataegis can result from multiple cytosine deaminations catalyzed by the AID/APOBEC family of proteins. This package contains functions to detect kataegis from SNVs in BED format. This package reports two scores per kataegic event, a hypermutation score and an APOBEC mediated kataegic score. Yousif, F. et al.; The Origins and Consequences of Localized and Global Somatic Hypermutation; Biorxiv 2018
|Author||Fouad Yousif, Xihui Lin, Fan Fan, Christopher Lalansingh|
|Date of publication||2018-03-29 21:57:09 UTC|
|Maintainer||Paul C. Boutros <[email protected]>|
|Package repository||View on CRAN|
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