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SeqKat: Detection of Kataegis
Kataegis is a localized hypermutation occurring when a region is enriched in somatic SNVs. Kataegis can result from multiple cytosine deaminations catalyzed by the AID/APOBEC family of proteins. This package contains functions to detect kataegis from SNVs in BED format. This package reports two scores per kataegic event, a hypermutation score and an APOBEC mediated kataegic score. Yousif, F. et al.; The Origins and Consequences of Localized and Global Somatic Hypermutation; Biorxiv 2018 <doi:10.1101/287839>.
Package details |
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| Author | Fouad Yousif, Xihui Lin, Fan Fan, Christopher Lalansingh, John Macdonald |
| Maintainer | Paul C. Boutros <pboutros@mednet.ucla.edu> |
| License | GPL-2 |
| Version | 0.0.8 |
| Package repository | View on CRAN |
| Installation |
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