Nothing
R/bayessurvreg3.R
In bayesSurv: Bayesian Survival Regression with Flexible Error and Random Effects Distributions
################################################
#### AUTHOR: Arnost Komarek ####
#### (2005) ####
#### ####
#### FILE: bayessurvreg3.R ####
#### ####
#### FUNCTIONS: bayessurvreg3 ####
################################################
### ======================================
### bayessurvreg3
### ======================================
## Survival regression with G-spline random intercept
## and G-spline error
##
## 01/02/2005: start working on it
## 02/02/2005: finished
## 07/12/2006: extension allowing inclulsion of the estimated correlation between the onset and time-to-event random intercepts
## 31/05/2013: extension allowing for misclassification of the event status added
## (cooperation with Maria Jose Garcia Zattera and Alejandro Jara)
##
bayessurvreg3 <- function
( formula,
random,
formula2,
random2,
data = parent.frame(),
classification,
classParam = list(Model = c("Examiner", "Factor:Examiner"),
a.sens = 1, b.sens = 1, a.spec = 1, b.spec = 1,
init.sens = NULL, init.spec = NULL),
na.action = na.fail,
onlyX = FALSE,
nsimul = list(niter = 10, nthin = 1, nburn = 0, nwrite = 10),
prior,
prior.beta,
prior.b,
init = list(iter = 0),
mcmc.par = list(type.update.a = "slice", k.overrelax.a = 1, k.overrelax.sigma = 1, k.overrelax.scale = 1,
type.update.a.b = "slice", k.overrelax.a.b = 1, k.overrelax.sigma.b = 1, k.overrelax.scale.b = 1),
prior2,
prior.beta2,
prior.b2,
init2,
mcmc.par2 = list(type.update.a = "slice", k.overrelax.a = 1, k.overrelax.sigma = 1, k.overrelax.scale = 1,
type.update.a.b = "slice", k.overrelax.a.b = 1, k.overrelax.sigma.b = 1, k.overrelax.scale.b = 1),
priorinit.Nb,
rho = list(type.update = "fixed.zero", init = 0, sigmaL = 0.1),
store = list(a = FALSE, a2 = FALSE, y = FALSE, y2 = FALSE, r = FALSE, r2 = FALSE, b = FALSE, b2 = FALSE,
a.b = FALSE, a.b2 = FALSE, r.b = FALSE, r.b2 = FALSE),
dir)
{
thispackage = "bayesSurv"
#thispackage = NULL
store <- bayessurvreg3.checkStore(store)
nsimul <- bayessurvreg.checknsimul(nsimul)
transform = function(t){log(t)}
dtransform = function(t){1/t}
transform2 = function(t){t}
dtransform2 = function(t){1}
## Give a function call to be recorded in a resulting object.
call <- match.call(expand.dots = TRUE)
## Extract all the design information from the function call
## Do not transform the response at this moment
doubly <- ifelse(missing(formula2), FALSE, TRUE)
m <- match.call(expand.dots = FALSE)
des <- bayessurvreg.design(m = m, formula = formula, random = random, data = data, transform = transform2, dtransform = transform2)
if (doubly) des2 <- bayessurvreg.design(m = m, formula = formula2, random = random2, data = data, transform = transform2, dtransform = transform2)
else des2 <- list(nX = 0, n = des$n, nrandom = 0, randomInt = FALSE)
if (onlyX){
if (doubly) return(list(X = des$X, X2 = des2$X))
else return(des$X)
}
if (!des$nrandom){
store$b <- FALSE
store$a.b <- FALSE
store$r.b <- FALSE
}
if (!des2$nrandom){
store$b2 <- FALSE
store$a.b2 <- FALSE
store$r.b2 <- FALSE
}
## Perform some checks
if (des$nrandom > 1) stop("Only intercept may appear in 'random'")
if (des$nrandom & !des$randomInt) stop("Only intercept may appear in 'random'")
if (des2$nrandom > 1) stop("Only intercept may appear in 'random2'")
if (des2$nrandom & !des2$randomInt) stop("Only intercept may appear in 'random2'")
nobs <- des$n
if (doubly){
nobs2 <- des2$n
if (nobs != nobs2) stop("Inconsistent formula and formula2 (different number of observations indicated)")
}
### ------------------------------------------------------------------------------------
### 201305: Code related to misclassification models
### ------------------------------------------------------------------------------------
if (missing(classification)){
mclass <- list(Model = "NONE", nModel = 0, nvisit = rep(1, nobs),
nExaminer = 0, labelExaminer = "0", Examiner = rep(0, nobs),
nFactor = 0, labelFactor = "0", Factor = rep(0, nobs),
Prior = rep(1, 4),
logTime = 0, Status = 0,
init.sens = 0, init.spec = 0)
## mclass$nModel == 0 ==> no misclassification model
}else{
if (doubly) stop("misclassification model not (yet) implemented for doubly-interval-censored data.")
mclass <- list() ## To keep the information being then passed to C++
if (!is.data.frame(classification)) stop("classification must be a data.frame")
if (ncol(classification) < 4) stop("too low number of columns in the classification data.frame")
if (ncol(classification) == 4){
colnames(classification) <- c("idUnit", "Time", "Examiner", "Status")
classification[, "Factor"] <- 0
}else{
classification <- classification[, 1:5]
colnames(classification) <- c("idUnit", "Time", "Examiner", "Status", "Factor")
}
### Some checks
if (any(is.na(classification[, "idUnit"]))) stop("NA's not allowed in the idUnit column of classification.")
if (any(is.na(classification[, "Time"]))) stop("NA's not allowed in the Time column of classification.")
if (any(classification[, "Time"] <= 0)) stop("all values in the Time column of classification must be positive.")
if (any(is.na(classification[, "Examiner"]))) stop("NA's not allowed in the Examiner column of classification.")
if (any(is.na(classification[, "Status"]))) stop("NA's not allowed in the Status column of classification.")
if (any(!(classification[, "Status"] %in% c(0, 1)))) stop("all values in the Status column of classification must be 0/1.")
### idUnit values that appear in the data
IDUnit <- unique(classification[, "idUnit"]) ### This maintains original ordering
### Consistency check
if (length(IDUnit) != nobs) stop("classification data.frame not consistent with the survival data (different number of experimental units)")
### Misclassification model
classParam$Model <- classParam$Model[1]
mclass$Model <- classParam$Model
mclass$nModel <- pmatch(mclass$Model, table = c("Examiner", "Factor:Examiner"))
if (is.na(mclass$nModel)) stop("unknown classParam$Model specified.")
### Number of visits per unit (tooth)
mclass$nvisit <- as.numeric(table(factor(classification[, "idUnit"], levels = IDUnit))) ### Also here, the original ordering is maintained
### Number of examinators
mclass$nExaminer <- length(unique(classification[, "Examiner"]))
### Examiners labeled 0, ..., nExaminer - 1 and their original labels
mclass$labelExaminer <- levels(factor(classification[, "Examiner"]))
mclass$Examiner <- as.numeric(factor(classification[, "Examiner"])) - 1
### Factor related variables (if needed)
switch (mclass$Model,
"Examiner" = {
mclass$nFactor <- 1
mclass$labelFactor <- "0"
mclass$Factor <- rep(0, sum(mclass$nvisit))
},
"Factor:Examiner" = {
### Number of unique values of Factor
mclass$nFactor <- length(unique(classification[, "Factor"]))
### Factor values labeled 0, ..., nFactor - 1 and their original labels
mclass$labelFactor <- levels(factor(classification[, "Factor"]))
mclass$Factor <- as.numeric(factor(classification[, "Factor"])) - 1
},
stop("some part of the code not yet implemented for this option.")
)
### Prior parameters
if (is.null(classParam$a.sens)) classParam$a.sens <- 1
if (is.null(classParam$b.sens)) classParam$b.sens <- 1
if (is.null(classParam$a.spec)) classParam$a.spec <- 1
if (is.null(classParam$b.spec)) classParam$b.spec <- 1
if (classParam$a.sens <= 0 | classParam$b.sens <= 0 | classParam$a.spec <= 0 | classParam$b.spec <= 0) stop("incorrect prior parameter for misclassification sensitivities/specificities")
mclass$Prior <- c(classParam$a.sens, classParam$b.sens, classParam$a.spec, classParam$b.spec)
names(mclass$Prior) <- c("a.sens", "b.sens", "a.spec", "b.spec")
### Transformation of the visit times
mclass$logTime <- log(classification[, "Time"])
### Status
mclass$Status <- classification[, "Status"]
### Initial sensitivities
if (is.null(classParam$init.sens)){
switch (mclass$Model,
"Examiner" = {
classParam$init.sens <- runif(mclass$nExaminer, min = 0.80, max = 0.90)
names(classParam$init.sens) <- mclass$labelExaminer
},
"Factor:Examiner" = {
classParam$init.sens <- matrix(runif(mclass$nFactor * mclass$nExaminer, min = 0.80, max = 0.90), nrow = mclass$nFactor, ncol = mclass$nExaminer)
rownames(classParam$init.sens) <- mclass$labelFactor
colnames(classParam$init.sens) <- mclass$labelExaminer
},
stop("some part of the code not yet implemented for this option.")
)
}
if (length(classParam$init.sens) != mclass$nFactor * mclass$nExaminer) stop("incorrect classParam$init.sens specified")
if (any(is.na(classParam$init.sens))) stop("NA's not allowed in classParam$init.sens")
if (any(classParam$init.sens <= 0) | any(classParam$init.sens >= 1)) stop("all classParam$init.sens must lie in (0, 1)")
mclass$init.sens <- as.numeric(classParam$init.sens)
### Initial specificities
if (is.null(classParam$init.spec)){
switch (mclass$Model,
"Examiner" = {
classParam$init.spec <- runif(mclass$nExaminer, min = 0.80, max = 0.90)
names(classParam$init.spec) <- mclass$labelExaminer
},
"Factor:Examiner" = {
classParam$init.spec <- matrix(runif(mclass$nFactor * mclass$nExaminer, min = 0.80, max = 0.90), nrow = mclass$nFactor, ncol = mclass$nExaminer)
rownames(classParam$init.spec) <- mclass$labelFactor
colnames(classParam$init.spec) <- mclass$labelExaminer
},
stop("some part of the code not yet implemented for this option.")
)
}
if (length(classParam$init.spec) != mclass$nFactor * mclass$nExaminer) stop("incorrect classParam$init.spec specified")
if (any(is.na(classParam$init.spec))) stop("NA's not allowed in classParam$init.spec")
if (any(classParam$init.spec <= 0) | any(classParam$init.spec >= 1)) stop("all classParam$init.spec must lie in (0, 1)")
mclass$init.spec <- as.numeric(classParam$init.spec)
}
### ------------------------------------------------------------------------------------
## Priors and inits for beta parameters
if (missing(init)) init <- list()
if (missing(init2)) init2 <- list()
if (missing(mcmc.par)) mcmc.par <- list()
if (missing(mcmc.par2)) mcmc.par2 <- list()
if (!doubly) mcmc.par2 <- list()
if (missing(prior.beta)) prior.beta <- list()
betadi <- bayessurvreg3.priorBeta(prior.beta, init, des)
init$beta <- attr(betadi, "init")
prior.beta <- attr(betadi, "prior.beta")
if (missing(prior.beta2)) prior.beta2 <- list()
betadi2 <- bayessurvreg3.priorBeta(prior.beta2, init2, des2)
init2$beta <- attr(betadi2, "init")
prior.beta2 <- attr(betadi2, "prior.beta")
## Priors and inits for rho (correlation coefficient between two random intercepts)
if (missing(priorinit.Nb)){
rho <- bayessurvreg3.checkrho(rho=rho, doubly=doubly)
if (rho$type.update == "fixed.zero") version <- 3
else version <- 31
}
else{
rho <- list(type.update = "fixed.zero", init=0, sigmaL=0.1)
rho <- bayessurvreg3.checkrho(rho=rho, doubly=doubly)
version <- 32
}
## Priors and inits for random intercept
if (version %in% c(3, 31)){
if (missing(prior.b)) prior.b <- list()
reffdi <- bayessurvreg3.priorb(prior.b=prior.b, init=init, design=des, mcmc.par=mcmc.par)
prior.b <- attr(reffdi, "prior.b")
init <- attr(reffdi, "init")
mcmc.par <- attr(reffdi, "mcmc.par")
## Priors and inits for random intercept
if (missing(prior.b2)) prior.b2 <- list()
reffdi2 <- bayessurvreg3.priorb(prior.b=prior.b2, init=init2, design=des2, mcmc.par=mcmc.par2)
prior.b2 <- attr(reffdi2, "prior.b")
init2 <- attr(reffdi2, "init")
mcmc.par2 <- attr(reffdi2, "mcmc.par")
}
else{
if (version == 32){
Reff <- bayessurvreg3.priorinitNb(priorinit.Nb=priorinit.Nb, init=init, init2=init2, design=des, design2=des2, doubly=doubly)
reffdi <- Reff$reffdi
reffdi2 <- Reff$reffdi2
priorinit.Nb <- attr(Reff, "priorinit.Nb")
init <- attr(Reff, "init")
init2 <- attr(Reff, "init2")
rm(list="Reff")
}
else{
stop("It is strange but I cannot determine the version to be used")
}
}
## Priors and inits for error G-spline, (censored) observations and observational allocations
if (!doubly) prior2 <- list()
prinit <- bayessurvreg3.priorInit(prior, init, des, mcmc.par, prior2, init2, des2, mcmc.par2, doubly)
init <- attr(prinit, "init")
prior <- attr(prinit, "prior")
mcmc.par <- attr(prinit, "mcmc.par")
init2 <- attr(prinit, "init2")
prior2 <- attr(prinit, "prior2")
mcmc.par2 <- attr(prinit, "mcmc.par2")
## Compute quantities to determine the space needed to be allocated
## and numbers of iterations in different phases
if (nsimul$nburn >= nsimul$niter) nsimul$nburn <- nsimul$niter - 1
if (nsimul$nburn < 0) nsimul$nburn <- 0
if (nsimul$nburn == 0) nruns <- 1
else nruns <- 2
nrun <- numeric(2)
nrun[2] <- nsimul$niter - nsimul$nburn
nrun[1] <- nsimul$nburn
nwrite.run <- nrun
nwrite.run[nsimul$nwrite <= nrun] <- nsimul$nwrite
max.nwrite <- max(nwrite.run)
## Write headers to files with stored values
bayessurvreg3.writeHeaders(dir = dir, doubly = doubly, prior.init = prinit,
priorb.di = reffdi, priorb2.di = reffdi2, store = store, design = des, design2 = des2, version = version,
mclass = mclass)
## Combine similar parameters into one vector
dims <- c(nobs, as.numeric(doubly))
storeV <- c(store$a, store$y, store$r, store$b, store$a2, store$y2, store$r2, store$b2, store$a.b, store$r.b, store$a.b2, store$r.b2)
nsimul.run1 <- c(nrun[1], nsimul$nthin, nwrite.run[1])
nsimul.run2 <- c(nrun[2], nsimul$nthin, nwrite.run[2])
names(nsimul.run1) <- names(nsimul.run2) <- c("niter", "nthin", "nwrite")
nsample1 <- nsimul.run1["niter"] %/% nsimul.run1["nthin"]
nsample2 <- nsimul.run2["niter"] %/% nsimul.run2["nthin"]
cat("Simulation started on ", date(), "\n", sep = "")
fit <- .C(C_bayessurvreg2, as.character(dir),
dims = as.integer(dims),
X1 = as.double(if(des$nX) t(des$X) else 0),
X2 = as.double(if(des2$nX) t(des2$X) else 0),
y1.left = as.double(prinit$y.left),
y1.right = as.double(prinit$y.right),
status1 = as.integer(prinit$status),
t2.left = as.double(prinit$t2.left),
t2.right = as.double(prinit$t2.right),
status2 = as.integer(prinit$status2),
iPML = double(dims[1]),
Ys1 = as.double(prinit$y),
Ys2 = as.double(prinit$y2),
r1 = as.integer(prinit$r),
r2 = as.integer(prinit$r2),
specif = as.integer(prinit$specification),
r1.b = as.integer(reffdi$r),
r2.b = as.integer(reffdi2$r),
specif.b = as.integer(c(reffdi$specification, reffdi2$specification)),
GsplI1 = as.integer(prinit$Gparmi),
GsplD1 = as.double(prinit$Gparmd),
GsplI2 = as.integer(prinit$Gparmi2),
GsplD2 = as.double(prinit$Gparmd2),
priorBetaI1 = as.integer(betadi$parmI),
priorBetaD1 = as.double(betadi$parmD),
priorBetaI2 = as.integer(betadi2$parmI),
priorBetaD2 = as.double(betadi2$parmD),
priorbI1 = as.integer(reffdi$bparmI),
priorbD1 = as.double(reffdi$bparmD),
priorbI2 = as.integer(reffdi2$bparmI),
priorbD2 = as.double(reffdi2$bparmD),
priorCovMatI1 = as.integer(reffdi$GsplI),
priorCovMatD1 = as.double(reffdi$GsplD),
priorCovMatI2 = as.integer(reffdi2$GsplI),
priorCovMatD2 = as.double(reffdi2$GsplD),
rho = as.double(rho$init),
rho.accept = integer(nsample1),
rho.type.update = as.integer(rho$typeI),
rho.sigmaL = as.double(rho$sigmaL),
mclass.sens.spec = as.double(c(mclass$init.sens, mclass$init.spec)),
mclass.logtime = as.double(mclass$logTime),
mclass.status = as.integer(mclass$Status),
mclass.paramI = as.integer(c(mclass$nModel, mclass$nExaminer, mclass$nFactor, mclass$nvisit, mclass$Examiner, mclass$Factor)),
mclass.paramD = as.double(mclass$Prior),
iter = as.integer(prinit$iter),
nsimul = as.integer(nsimul.run1),
store = as.integer(storeV),
version = as.integer(version),
mainSimul = as.integer(0),
err = integer(1),
PACKAGE = thispackage)
if (fit$err != 0) stop ("Something went wrong during the simulation.")
cat("Burn-up finished on ", date(), " (iteration ", fit$iter, ")", "\n", sep = "")
## Rewrite sampled values by new files
bayessurvreg3.writeHeaders(dir = dir, doubly = doubly, prior.init = prinit,
priorb.di = reffdi, priorb2.di = reffdi2, store = store, design = des, design2 = des2, version = version,
mclass = mclass)
## Main simulation
fit <- .C(C_bayessurvreg2, as.character(dir),
dims = as.integer(dims),
X1 = as.double(fit$X1),
X2 = as.double(fit$X2),
y1.left = as.double(fit$y1.left),
y1.right = as.double(fit$y1.right),
status1 = as.integer(fit$status1),
t2.left = as.double(fit$t2.left),
t2.right = as.double(fit$t2.right),
status2 = as.integer(fit$status2),
iPML = double(dims[1]),
Ys1 = as.double(fit$Ys1),
Ys2 = as.double(fit$Ys2),
r1 = as.integer(fit$r1),
r2 = as.integer(fit$r2),
specif = as.integer(fit$specif),
r1.b = as.integer(fit$r1.b),
r2.b = as.integer(fit$r2.b),
specif.b = as.integer(fit$specif.b),
GsplI1 = as.integer(fit$GsplI1),
GsplD1 = as.double(fit$GsplD1),
GsplI2 = as.integer(fit$GsplI2),
GsplD2 = as.double(fit$GsplD2),
priorBetaI1 = as.integer(fit$priorBetaI1),
priorBetaD1 = as.double(fit$priorBetaD1),
priorBetaI2 = as.integer(fit$priorBetaI2),
priorBetaD2 = as.double(fit$priorBetaD2),
priorbI1 = as.integer(fit$priorbI1),
priorbD1 = as.double(fit$priorbD1),
priorbI2 = as.integer(fit$priorbI2),
priorbD2 = as.double(fit$priorbD2),
priorCovMatI1 = as.integer(fit$priorCovMatI1),
priorCovMatD1 = as.double(fit$priorCovMatD1),
priorCovMatI2 = as.integer(fit$priorCovMatI2),
priorCovMatD2 = as.double(fit$priorCovMatD2),
rho = as.double(fit$rho),
rho.accept = integer(nsample2),
rho.type.update = as.integer(fit$rho.type.update),
rho.sigmaL = as.double(fit$rho.sigmaL),
mclass.sens.spec = as.double(fit$mclass.sens.spec),
mclass.logtime = as.double(mclass$logTime),
mclass.status = as.integer(mclass$Status),
mclass.paramI = as.integer(c(mclass$nModel, mclass$nExaminer, mclass$nFactor, mclass$nvisit, mclass$Examiner, mclass$Factor)),
mclass.paramD = as.double(mclass$Prior),
iter = as.integer(fit$iter),
nsimul = as.integer(nsimul.run2),
store = as.integer(fit$store),
version = as.integer(fit$version),
mainSimul = as.integer(1),
err = integer(1),
PACKAGE = thispackage)
if (fit$err != 0) stop ("Something went wrong during the simulation.")
cat("Simulation finished on ", date(), " (iteration ", fit$iter, ")", "\n", sep = "")
toreturn <- fit$iter
attr(toreturn, "call") <- call
attr(toreturn, "init") <- init
attr(toreturn, "prior") <- prior
attr(toreturn, "prior.beta") <- prior.beta
attr(toreturn, "mcmc.par") <- mcmc.par
if (doubly){
attr(toreturn, "init2") <- init2
attr(toreturn, "prior2") <- prior2
attr(toreturn, "prior.beta2") <- prior.beta2
attr(toreturn, "mcmc.par2") <- mcmc.par2
}
if (version %in% c(3, 31)){
attr(toreturn, "prior.b") <- prior.b
if (doubly) attr(toreturn, "prior.b2") <- prior.b2
}
if (version == 31){
attr(toreturn, "rho.accept") <- fit$rho.accept
}
if (version == 32){
attr(toreturn, "priorinit.Nb") <- fit$priorinit.Nb
}
if (mclass$nModel){
attr(toreturn, "prior.classification") <- mclass$Prior
attr(toreturn, "init.sens") <- classParam$init.sens
attr(toreturn, "init.spec") <- classParam$init.spec
##### Calculate model fit statistics
##### -----------------------------------
### Deviance sample
devGJK <- scan(paste(dir, "/devianceGJK.sim", sep = ""), skip = 1, quiet = TRUE)
D.bar <- mean(devGJK, na.rm = TRUE)
### Posterior means of sensitivities/specificities
sensspec <- matrix(scan(paste(dir, "/sens_spec.sim", sep = ""), skip = 1, quiet = TRUE), ncol = 2 * mclass$nExaminer * mclass$nFactor, byrow = TRUE)
colnames(sensspec) <- scan(paste(dir, "/sens_spec.sim", sep = ""), what = character(), nlines = 1, quiet = TRUE)
sensspec.bar <- apply(sensspec, 2, mean, na.rm = TRUE)
rm(list = "sensspec")
### Init for posterior means of linear predictors
eta.bar <- rep(0, des$n)
### Posterior means of random effects
if (des$nrandom > 0){
if (store$b){
bb <- matrix(scan(paste(dir, "/b.sim", sep = ""), skip = 1, quiet = TRUE), ncol = des$ncluster, byrow = TRUE)
bb.bar <- apply(bb, 2, mean, na.rm = TRUE)
rm(list = "bb")
}else{
bb.bar <- rep(NA, des$ncluster)
warning("to have DIC calculated, store$b must be TRUE.")
}
eta.bar <- eta.bar + rep(bb.bar, des$nwithin)
}
### Posterior means of fixed effects
if (des$nX){
beta <- matrix(scan(paste(dir, "/beta.sim", sep = ""), skip = 1, quiet = TRUE), ncol = des$nX, byrow = TRUE)
colnames(beta) <- scan(paste(dir, "/beta.sim", sep = ""), what = character(), nlines = 1, quiet = TRUE)
beta.bar <- apply(beta, 2, mean, na.rm = TRUE)
rm(list = "beta")
eta.bar <- eta.bar + as.numeric(des$X %*% beta.bar)
}
### Posterior means of G-spline (error term) parameters
gspline <- matrix(scan(paste(dir, "/gspline.sim", sep = ""), skip = 1, quiet = TRUE), ncol = 5, byrow = TRUE)
colnames(gspline) <- scan(paste(dir, "/gspline.sim", sep = ""), what = character(), nlines = 1, quiet = TRUE)
gspline.bar <- apply(gspline, 2, mean, na.rm = TRUE)
gspline.sigmaSq.bar <- mean(gspline[, "sigma1"]^2, na.rm = TRUE)
gspline.scaleSq.bar <- mean(gspline[, "scale1"]^2, na.rm = TRUE)
rm(list = "gspline")
mweight <- matrix(scan(paste(dir, "/mweight.sim", sep = ""), skip = 1, quiet = TRUE), ncol = 2 * prinit$Gparmi["K1"] + 1, byrow = TRUE)
mweight.bar <- apply(mweight, 2, mean, na.rm = TRUE)
rm(list = "mweight")
### Input for D.in.bar to be calculated in C++
if (any(is.na(eta.bar))){
D.in.bar <- NA
}else{
maxnvisit <- max(mclass$nvisit)
nss <- mclass$nExaminer * mclass$nFactor
inD <- .C(C_iPML_misclass_GJK,
iPML = double(des$n),
dwork = double(3 * (1 + maxnvisit)),
min_etaM = as.double((-1) * eta.bar),
sens = as.double(sensspec.bar[1:nss]),
spec = as.double(sensspec.bar[(nss + 1):(2 * nss)]),
logvtime = as.double(mclass$logTime),
status = as.integer(mclass$Status),
nExaminer = as.integer(mclass$nExaminer),
nFactor = as.integer(mclass$nFactor),
nvisit = as.integer(mclass$nvisit),
maxnvisit = as.integer(maxnvisit),
Examiner = as.integer(mclass$Examiner),
Factor = as.integer(mclass$Factor),
gg_K = as.integer(prinit$Gparmi["K1"]),
gg_gamma = as.double(gspline.bar["gamma1"]),
gg_delta = as.double(gspline.bar["delta1"]),
gg_sigma = as.double(sqrt(gspline.sigmaSq.bar)),
#gg_sigma = as.double(gspline.bar["sigma1"]),
gg_intcpt = as.double(gspline.bar["intercept1"]),
gg_scale = as.double(sqrt(gspline.scaleSq.bar)),
#gg_scale = as.double(gspline.bar["scale1"]),
gg_w = as.double(mweight.bar),
nP = as.integer(des$n),
PACKAGE = thispackage)
D.in.bar <- -2 * sum(log(inD$iPML))
}
### DIC and log(PML)
pD <- D.bar - D.in.bar
DIC <- D.bar + pD
logPML <- sum(log(fit$iPML))
attr(toreturn, "fitStat") <- c(logPML, DIC, D.bar, D.in.bar, pD)
names(attr(toreturn, "fitStat")) <- c("logPML", "DIC", "D.bar", "D.in.bar", "pD")
attr(toreturn, "iPML") <- fit$iPML
}
class(toreturn) <- "bayessurvreg3"
return(toreturn)
}
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################################################
#### AUTHOR: Arnost Komarek ####
#### (2005) ####
#### ####
#### FILE: bayessurvreg3.R ####
#### ####
#### FUNCTIONS: bayessurvreg3 ####
################################################
### ======================================
### bayessurvreg3
### ======================================
## Survival regression with G-spline random intercept
## and G-spline error
##
## 01/02/2005: start working on it
## 02/02/2005: finished
## 07/12/2006: extension allowing inclulsion of the estimated correlation between the onset and time-to-event random intercepts
## 31/05/2013: extension allowing for misclassification of the event status added
## (cooperation with Maria Jose Garcia Zattera and Alejandro Jara)
##
bayessurvreg3 <- function
( formula,
random,
formula2,
random2,
data = parent.frame(),
classification,
classParam = list(Model = c("Examiner", "Factor:Examiner"),
a.sens = 1, b.sens = 1, a.spec = 1, b.spec = 1,
init.sens = NULL, init.spec = NULL),
na.action = na.fail,
onlyX = FALSE,
nsimul = list(niter = 10, nthin = 1, nburn = 0, nwrite = 10),
prior,
prior.beta,
prior.b,
init = list(iter = 0),
mcmc.par = list(type.update.a = "slice", k.overrelax.a = 1, k.overrelax.sigma = 1, k.overrelax.scale = 1,
type.update.a.b = "slice", k.overrelax.a.b = 1, k.overrelax.sigma.b = 1, k.overrelax.scale.b = 1),
prior2,
prior.beta2,
prior.b2,
init2,
mcmc.par2 = list(type.update.a = "slice", k.overrelax.a = 1, k.overrelax.sigma = 1, k.overrelax.scale = 1,
type.update.a.b = "slice", k.overrelax.a.b = 1, k.overrelax.sigma.b = 1, k.overrelax.scale.b = 1),
priorinit.Nb,
rho = list(type.update = "fixed.zero", init = 0, sigmaL = 0.1),
store = list(a = FALSE, a2 = FALSE, y = FALSE, y2 = FALSE, r = FALSE, r2 = FALSE, b = FALSE, b2 = FALSE,
a.b = FALSE, a.b2 = FALSE, r.b = FALSE, r.b2 = FALSE),
dir)
{
thispackage = "bayesSurv"
#thispackage = NULL
store <- bayessurvreg3.checkStore(store)
nsimul <- bayessurvreg.checknsimul(nsimul)
transform = function(t){log(t)}
dtransform = function(t){1/t}
transform2 = function(t){t}
dtransform2 = function(t){1}
## Give a function call to be recorded in a resulting object.
call <- match.call(expand.dots = TRUE)
## Extract all the design information from the function call
## Do not transform the response at this moment
doubly <- ifelse(missing(formula2), FALSE, TRUE)
m <- match.call(expand.dots = FALSE)
des <- bayessurvreg.design(m = m, formula = formula, random = random, data = data, transform = transform2, dtransform = transform2)
if (doubly) des2 <- bayessurvreg.design(m = m, formula = formula2, random = random2, data = data, transform = transform2, dtransform = transform2)
else des2 <- list(nX = 0, n = des$n, nrandom = 0, randomInt = FALSE)
if (onlyX){
if (doubly) return(list(X = des$X, X2 = des2$X))
else return(des$X)
}
if (!des$nrandom){
store$b <- FALSE
store$a.b <- FALSE
store$r.b <- FALSE
}
if (!des2$nrandom){
store$b2 <- FALSE
store$a.b2 <- FALSE
store$r.b2 <- FALSE
}
## Perform some checks
if (des$nrandom > 1) stop("Only intercept may appear in 'random'")
if (des$nrandom & !des$randomInt) stop("Only intercept may appear in 'random'")
if (des2$nrandom > 1) stop("Only intercept may appear in 'random2'")
if (des2$nrandom & !des2$randomInt) stop("Only intercept may appear in 'random2'")
nobs <- des$n
if (doubly){
nobs2 <- des2$n
if (nobs != nobs2) stop("Inconsistent formula and formula2 (different number of observations indicated)")
}
### ------------------------------------------------------------------------------------
### 201305: Code related to misclassification models
### ------------------------------------------------------------------------------------
if (missing(classification)){
mclass <- list(Model = "NONE", nModel = 0, nvisit = rep(1, nobs),
nExaminer = 0, labelExaminer = "0", Examiner = rep(0, nobs),
nFactor = 0, labelFactor = "0", Factor = rep(0, nobs),
Prior = rep(1, 4),
logTime = 0, Status = 0,
init.sens = 0, init.spec = 0)
## mclass$nModel == 0 ==> no misclassification model
}else{
if (doubly) stop("misclassification model not (yet) implemented for doubly-interval-censored data.")
mclass <- list() ## To keep the information being then passed to C++
if (!is.data.frame(classification)) stop("classification must be a data.frame")
if (ncol(classification) < 4) stop("too low number of columns in the classification data.frame")
if (ncol(classification) == 4){
colnames(classification) <- c("idUnit", "Time", "Examiner", "Status")
classification[, "Factor"] <- 0
}else{
classification <- classification[, 1:5]
colnames(classification) <- c("idUnit", "Time", "Examiner", "Status", "Factor")
}
### Some checks
if (any(is.na(classification[, "idUnit"]))) stop("NA's not allowed in the idUnit column of classification.")
if (any(is.na(classification[, "Time"]))) stop("NA's not allowed in the Time column of classification.")
if (any(classification[, "Time"] <= 0)) stop("all values in the Time column of classification must be positive.")
if (any(is.na(classification[, "Examiner"]))) stop("NA's not allowed in the Examiner column of classification.")
if (any(is.na(classification[, "Status"]))) stop("NA's not allowed in the Status column of classification.")
if (any(!(classification[, "Status"] %in% c(0, 1)))) stop("all values in the Status column of classification must be 0/1.")
### idUnit values that appear in the data
IDUnit <- unique(classification[, "idUnit"]) ### This maintains original ordering
### Consistency check
if (length(IDUnit) != nobs) stop("classification data.frame not consistent with the survival data (different number of experimental units)")
### Misclassification model
classParam$Model <- classParam$Model[1]
mclass$Model <- classParam$Model
mclass$nModel <- pmatch(mclass$Model, table = c("Examiner", "Factor:Examiner"))
if (is.na(mclass$nModel)) stop("unknown classParam$Model specified.")
### Number of visits per unit (tooth)
mclass$nvisit <- as.numeric(table(factor(classification[, "idUnit"], levels = IDUnit))) ### Also here, the original ordering is maintained
### Number of examinators
mclass$nExaminer <- length(unique(classification[, "Examiner"]))
### Examiners labeled 0, ..., nExaminer - 1 and their original labels
mclass$labelExaminer <- levels(factor(classification[, "Examiner"]))
mclass$Examiner <- as.numeric(factor(classification[, "Examiner"])) - 1
### Factor related variables (if needed)
switch (mclass$Model,
"Examiner" = {
mclass$nFactor <- 1
mclass$labelFactor <- "0"
mclass$Factor <- rep(0, sum(mclass$nvisit))
},
"Factor:Examiner" = {
### Number of unique values of Factor
mclass$nFactor <- length(unique(classification[, "Factor"]))
### Factor values labeled 0, ..., nFactor - 1 and their original labels
mclass$labelFactor <- levels(factor(classification[, "Factor"]))
mclass$Factor <- as.numeric(factor(classification[, "Factor"])) - 1
},
stop("some part of the code not yet implemented for this option.")
)
### Prior parameters
if (is.null(classParam$a.sens)) classParam$a.sens <- 1
if (is.null(classParam$b.sens)) classParam$b.sens <- 1
if (is.null(classParam$a.spec)) classParam$a.spec <- 1
if (is.null(classParam$b.spec)) classParam$b.spec <- 1
if (classParam$a.sens <= 0 | classParam$b.sens <= 0 | classParam$a.spec <= 0 | classParam$b.spec <= 0) stop("incorrect prior parameter for misclassification sensitivities/specificities")
mclass$Prior <- c(classParam$a.sens, classParam$b.sens, classParam$a.spec, classParam$b.spec)
names(mclass$Prior) <- c("a.sens", "b.sens", "a.spec", "b.spec")
### Transformation of the visit times
mclass$logTime <- log(classification[, "Time"])
### Status
mclass$Status <- classification[, "Status"]
### Initial sensitivities
if (is.null(classParam$init.sens)){
switch (mclass$Model,
"Examiner" = {
classParam$init.sens <- runif(mclass$nExaminer, min = 0.80, max = 0.90)
names(classParam$init.sens) <- mclass$labelExaminer
},
"Factor:Examiner" = {
classParam$init.sens <- matrix(runif(mclass$nFactor * mclass$nExaminer, min = 0.80, max = 0.90), nrow = mclass$nFactor, ncol = mclass$nExaminer)
rownames(classParam$init.sens) <- mclass$labelFactor
colnames(classParam$init.sens) <- mclass$labelExaminer
},
stop("some part of the code not yet implemented for this option.")
)
}
if (length(classParam$init.sens) != mclass$nFactor * mclass$nExaminer) stop("incorrect classParam$init.sens specified")
if (any(is.na(classParam$init.sens))) stop("NA's not allowed in classParam$init.sens")
if (any(classParam$init.sens <= 0) | any(classParam$init.sens >= 1)) stop("all classParam$init.sens must lie in (0, 1)")
mclass$init.sens <- as.numeric(classParam$init.sens)
### Initial specificities
if (is.null(classParam$init.spec)){
switch (mclass$Model,
"Examiner" = {
classParam$init.spec <- runif(mclass$nExaminer, min = 0.80, max = 0.90)
names(classParam$init.spec) <- mclass$labelExaminer
},
"Factor:Examiner" = {
classParam$init.spec <- matrix(runif(mclass$nFactor * mclass$nExaminer, min = 0.80, max = 0.90), nrow = mclass$nFactor, ncol = mclass$nExaminer)
rownames(classParam$init.spec) <- mclass$labelFactor
colnames(classParam$init.spec) <- mclass$labelExaminer
},
stop("some part of the code not yet implemented for this option.")
)
}
if (length(classParam$init.spec) != mclass$nFactor * mclass$nExaminer) stop("incorrect classParam$init.spec specified")
if (any(is.na(classParam$init.spec))) stop("NA's not allowed in classParam$init.spec")
if (any(classParam$init.spec <= 0) | any(classParam$init.spec >= 1)) stop("all classParam$init.spec must lie in (0, 1)")
mclass$init.spec <- as.numeric(classParam$init.spec)
}
### ------------------------------------------------------------------------------------
## Priors and inits for beta parameters
if (missing(init)) init <- list()
if (missing(init2)) init2 <- list()
if (missing(mcmc.par)) mcmc.par <- list()
if (missing(mcmc.par2)) mcmc.par2 <- list()
if (!doubly) mcmc.par2 <- list()
if (missing(prior.beta)) prior.beta <- list()
betadi <- bayessurvreg3.priorBeta(prior.beta, init, des)
init$beta <- attr(betadi, "init")
prior.beta <- attr(betadi, "prior.beta")
if (missing(prior.beta2)) prior.beta2 <- list()
betadi2 <- bayessurvreg3.priorBeta(prior.beta2, init2, des2)
init2$beta <- attr(betadi2, "init")
prior.beta2 <- attr(betadi2, "prior.beta")
## Priors and inits for rho (correlation coefficient between two random intercepts)
if (missing(priorinit.Nb)){
rho <- bayessurvreg3.checkrho(rho=rho, doubly=doubly)
if (rho$type.update == "fixed.zero") version <- 3
else version <- 31
}
else{
rho <- list(type.update = "fixed.zero", init=0, sigmaL=0.1)
rho <- bayessurvreg3.checkrho(rho=rho, doubly=doubly)
version <- 32
}
## Priors and inits for random intercept
if (version %in% c(3, 31)){
if (missing(prior.b)) prior.b <- list()
reffdi <- bayessurvreg3.priorb(prior.b=prior.b, init=init, design=des, mcmc.par=mcmc.par)
prior.b <- attr(reffdi, "prior.b")
init <- attr(reffdi, "init")
mcmc.par <- attr(reffdi, "mcmc.par")
## Priors and inits for random intercept
if (missing(prior.b2)) prior.b2 <- list()
reffdi2 <- bayessurvreg3.priorb(prior.b=prior.b2, init=init2, design=des2, mcmc.par=mcmc.par2)
prior.b2 <- attr(reffdi2, "prior.b")
init2 <- attr(reffdi2, "init")
mcmc.par2 <- attr(reffdi2, "mcmc.par")
}
else{
if (version == 32){
Reff <- bayessurvreg3.priorinitNb(priorinit.Nb=priorinit.Nb, init=init, init2=init2, design=des, design2=des2, doubly=doubly)
reffdi <- Reff$reffdi
reffdi2 <- Reff$reffdi2
priorinit.Nb <- attr(Reff, "priorinit.Nb")
init <- attr(Reff, "init")
init2 <- attr(Reff, "init2")
rm(list="Reff")
}
else{
stop("It is strange but I cannot determine the version to be used")
}
}
## Priors and inits for error G-spline, (censored) observations and observational allocations
if (!doubly) prior2 <- list()
prinit <- bayessurvreg3.priorInit(prior, init, des, mcmc.par, prior2, init2, des2, mcmc.par2, doubly)
init <- attr(prinit, "init")
prior <- attr(prinit, "prior")
mcmc.par <- attr(prinit, "mcmc.par")
init2 <- attr(prinit, "init2")
prior2 <- attr(prinit, "prior2")
mcmc.par2 <- attr(prinit, "mcmc.par2")
## Compute quantities to determine the space needed to be allocated
## and numbers of iterations in different phases
if (nsimul$nburn >= nsimul$niter) nsimul$nburn <- nsimul$niter - 1
if (nsimul$nburn < 0) nsimul$nburn <- 0
if (nsimul$nburn == 0) nruns <- 1
else nruns <- 2
nrun <- numeric(2)
nrun[2] <- nsimul$niter - nsimul$nburn
nrun[1] <- nsimul$nburn
nwrite.run <- nrun
nwrite.run[nsimul$nwrite <= nrun] <- nsimul$nwrite
max.nwrite <- max(nwrite.run)
## Write headers to files with stored values
bayessurvreg3.writeHeaders(dir = dir, doubly = doubly, prior.init = prinit,
priorb.di = reffdi, priorb2.di = reffdi2, store = store, design = des, design2 = des2, version = version,
mclass = mclass)
## Combine similar parameters into one vector
dims <- c(nobs, as.numeric(doubly))
storeV <- c(store$a, store$y, store$r, store$b, store$a2, store$y2, store$r2, store$b2, store$a.b, store$r.b, store$a.b2, store$r.b2)
nsimul.run1 <- c(nrun[1], nsimul$nthin, nwrite.run[1])
nsimul.run2 <- c(nrun[2], nsimul$nthin, nwrite.run[2])
names(nsimul.run1) <- names(nsimul.run2) <- c("niter", "nthin", "nwrite")
nsample1 <- nsimul.run1["niter"] %/% nsimul.run1["nthin"]
nsample2 <- nsimul.run2["niter"] %/% nsimul.run2["nthin"]
cat("Simulation started on ", date(), "\n", sep = "")
fit <- .C(C_bayessurvreg2, as.character(dir),
dims = as.integer(dims),
X1 = as.double(if(des$nX) t(des$X) else 0),
X2 = as.double(if(des2$nX) t(des2$X) else 0),
y1.left = as.double(prinit$y.left),
y1.right = as.double(prinit$y.right),
status1 = as.integer(prinit$status),
t2.left = as.double(prinit$t2.left),
t2.right = as.double(prinit$t2.right),
status2 = as.integer(prinit$status2),
iPML = double(dims[1]),
Ys1 = as.double(prinit$y),
Ys2 = as.double(prinit$y2),
r1 = as.integer(prinit$r),
r2 = as.integer(prinit$r2),
specif = as.integer(prinit$specification),
r1.b = as.integer(reffdi$r),
r2.b = as.integer(reffdi2$r),
specif.b = as.integer(c(reffdi$specification, reffdi2$specification)),
GsplI1 = as.integer(prinit$Gparmi),
GsplD1 = as.double(prinit$Gparmd),
GsplI2 = as.integer(prinit$Gparmi2),
GsplD2 = as.double(prinit$Gparmd2),
priorBetaI1 = as.integer(betadi$parmI),
priorBetaD1 = as.double(betadi$parmD),
priorBetaI2 = as.integer(betadi2$parmI),
priorBetaD2 = as.double(betadi2$parmD),
priorbI1 = as.integer(reffdi$bparmI),
priorbD1 = as.double(reffdi$bparmD),
priorbI2 = as.integer(reffdi2$bparmI),
priorbD2 = as.double(reffdi2$bparmD),
priorCovMatI1 = as.integer(reffdi$GsplI),
priorCovMatD1 = as.double(reffdi$GsplD),
priorCovMatI2 = as.integer(reffdi2$GsplI),
priorCovMatD2 = as.double(reffdi2$GsplD),
rho = as.double(rho$init),
rho.accept = integer(nsample1),
rho.type.update = as.integer(rho$typeI),
rho.sigmaL = as.double(rho$sigmaL),
mclass.sens.spec = as.double(c(mclass$init.sens, mclass$init.spec)),
mclass.logtime = as.double(mclass$logTime),
mclass.status = as.integer(mclass$Status),
mclass.paramI = as.integer(c(mclass$nModel, mclass$nExaminer, mclass$nFactor, mclass$nvisit, mclass$Examiner, mclass$Factor)),
mclass.paramD = as.double(mclass$Prior),
iter = as.integer(prinit$iter),
nsimul = as.integer(nsimul.run1),
store = as.integer(storeV),
version = as.integer(version),
mainSimul = as.integer(0),
err = integer(1),
PACKAGE = thispackage)
if (fit$err != 0) stop ("Something went wrong during the simulation.")
cat("Burn-up finished on ", date(), " (iteration ", fit$iter, ")", "\n", sep = "")
## Rewrite sampled values by new files
bayessurvreg3.writeHeaders(dir = dir, doubly = doubly, prior.init = prinit,
priorb.di = reffdi, priorb2.di = reffdi2, store = store, design = des, design2 = des2, version = version,
mclass = mclass)
## Main simulation
fit <- .C(C_bayessurvreg2, as.character(dir),
dims = as.integer(dims),
X1 = as.double(fit$X1),
X2 = as.double(fit$X2),
y1.left = as.double(fit$y1.left),
y1.right = as.double(fit$y1.right),
status1 = as.integer(fit$status1),
t2.left = as.double(fit$t2.left),
t2.right = as.double(fit$t2.right),
status2 = as.integer(fit$status2),
iPML = double(dims[1]),
Ys1 = as.double(fit$Ys1),
Ys2 = as.double(fit$Ys2),
r1 = as.integer(fit$r1),
r2 = as.integer(fit$r2),
specif = as.integer(fit$specif),
r1.b = as.integer(fit$r1.b),
r2.b = as.integer(fit$r2.b),
specif.b = as.integer(fit$specif.b),
GsplI1 = as.integer(fit$GsplI1),
GsplD1 = as.double(fit$GsplD1),
GsplI2 = as.integer(fit$GsplI2),
GsplD2 = as.double(fit$GsplD2),
priorBetaI1 = as.integer(fit$priorBetaI1),
priorBetaD1 = as.double(fit$priorBetaD1),
priorBetaI2 = as.integer(fit$priorBetaI2),
priorBetaD2 = as.double(fit$priorBetaD2),
priorbI1 = as.integer(fit$priorbI1),
priorbD1 = as.double(fit$priorbD1),
priorbI2 = as.integer(fit$priorbI2),
priorbD2 = as.double(fit$priorbD2),
priorCovMatI1 = as.integer(fit$priorCovMatI1),
priorCovMatD1 = as.double(fit$priorCovMatD1),
priorCovMatI2 = as.integer(fit$priorCovMatI2),
priorCovMatD2 = as.double(fit$priorCovMatD2),
rho = as.double(fit$rho),
rho.accept = integer(nsample2),
rho.type.update = as.integer(fit$rho.type.update),
rho.sigmaL = as.double(fit$rho.sigmaL),
mclass.sens.spec = as.double(fit$mclass.sens.spec),
mclass.logtime = as.double(mclass$logTime),
mclass.status = as.integer(mclass$Status),
mclass.paramI = as.integer(c(mclass$nModel, mclass$nExaminer, mclass$nFactor, mclass$nvisit, mclass$Examiner, mclass$Factor)),
mclass.paramD = as.double(mclass$Prior),
iter = as.integer(fit$iter),
nsimul = as.integer(nsimul.run2),
store = as.integer(fit$store),
version = as.integer(fit$version),
mainSimul = as.integer(1),
err = integer(1),
PACKAGE = thispackage)
if (fit$err != 0) stop ("Something went wrong during the simulation.")
cat("Simulation finished on ", date(), " (iteration ", fit$iter, ")", "\n", sep = "")
toreturn <- fit$iter
attr(toreturn, "call") <- call
attr(toreturn, "init") <- init
attr(toreturn, "prior") <- prior
attr(toreturn, "prior.beta") <- prior.beta
attr(toreturn, "mcmc.par") <- mcmc.par
if (doubly){
attr(toreturn, "init2") <- init2
attr(toreturn, "prior2") <- prior2
attr(toreturn, "prior.beta2") <- prior.beta2
attr(toreturn, "mcmc.par2") <- mcmc.par2
}
if (version %in% c(3, 31)){
attr(toreturn, "prior.b") <- prior.b
if (doubly) attr(toreturn, "prior.b2") <- prior.b2
}
if (version == 31){
attr(toreturn, "rho.accept") <- fit$rho.accept
}
if (version == 32){
attr(toreturn, "priorinit.Nb") <- fit$priorinit.Nb
}
if (mclass$nModel){
attr(toreturn, "prior.classification") <- mclass$Prior
attr(toreturn, "init.sens") <- classParam$init.sens
attr(toreturn, "init.spec") <- classParam$init.spec
##### Calculate model fit statistics
##### -----------------------------------
### Deviance sample
devGJK <- scan(paste(dir, "/devianceGJK.sim", sep = ""), skip = 1, quiet = TRUE)
D.bar <- mean(devGJK, na.rm = TRUE)
### Posterior means of sensitivities/specificities
sensspec <- matrix(scan(paste(dir, "/sens_spec.sim", sep = ""), skip = 1, quiet = TRUE), ncol = 2 * mclass$nExaminer * mclass$nFactor, byrow = TRUE)
colnames(sensspec) <- scan(paste(dir, "/sens_spec.sim", sep = ""), what = character(), nlines = 1, quiet = TRUE)
sensspec.bar <- apply(sensspec, 2, mean, na.rm = TRUE)
rm(list = "sensspec")
### Init for posterior means of linear predictors
eta.bar <- rep(0, des$n)
### Posterior means of random effects
if (des$nrandom > 0){
if (store$b){
bb <- matrix(scan(paste(dir, "/b.sim", sep = ""), skip = 1, quiet = TRUE), ncol = des$ncluster, byrow = TRUE)
bb.bar <- apply(bb, 2, mean, na.rm = TRUE)
rm(list = "bb")
}else{
bb.bar <- rep(NA, des$ncluster)
warning("to have DIC calculated, store$b must be TRUE.")
}
eta.bar <- eta.bar + rep(bb.bar, des$nwithin)
}
### Posterior means of fixed effects
if (des$nX){
beta <- matrix(scan(paste(dir, "/beta.sim", sep = ""), skip = 1, quiet = TRUE), ncol = des$nX, byrow = TRUE)
colnames(beta) <- scan(paste(dir, "/beta.sim", sep = ""), what = character(), nlines = 1, quiet = TRUE)
beta.bar <- apply(beta, 2, mean, na.rm = TRUE)
rm(list = "beta")
eta.bar <- eta.bar + as.numeric(des$X %*% beta.bar)
}
### Posterior means of G-spline (error term) parameters
gspline <- matrix(scan(paste(dir, "/gspline.sim", sep = ""), skip = 1, quiet = TRUE), ncol = 5, byrow = TRUE)
colnames(gspline) <- scan(paste(dir, "/gspline.sim", sep = ""), what = character(), nlines = 1, quiet = TRUE)
gspline.bar <- apply(gspline, 2, mean, na.rm = TRUE)
gspline.sigmaSq.bar <- mean(gspline[, "sigma1"]^2, na.rm = TRUE)
gspline.scaleSq.bar <- mean(gspline[, "scale1"]^2, na.rm = TRUE)
rm(list = "gspline")
mweight <- matrix(scan(paste(dir, "/mweight.sim", sep = ""), skip = 1, quiet = TRUE), ncol = 2 * prinit$Gparmi["K1"] + 1, byrow = TRUE)
mweight.bar <- apply(mweight, 2, mean, na.rm = TRUE)
rm(list = "mweight")
### Input for D.in.bar to be calculated in C++
if (any(is.na(eta.bar))){
D.in.bar <- NA
}else{
maxnvisit <- max(mclass$nvisit)
nss <- mclass$nExaminer * mclass$nFactor
inD <- .C(C_iPML_misclass_GJK,
iPML = double(des$n),
dwork = double(3 * (1 + maxnvisit)),
min_etaM = as.double((-1) * eta.bar),
sens = as.double(sensspec.bar[1:nss]),
spec = as.double(sensspec.bar[(nss + 1):(2 * nss)]),
logvtime = as.double(mclass$logTime),
status = as.integer(mclass$Status),
nExaminer = as.integer(mclass$nExaminer),
nFactor = as.integer(mclass$nFactor),
nvisit = as.integer(mclass$nvisit),
maxnvisit = as.integer(maxnvisit),
Examiner = as.integer(mclass$Examiner),
Factor = as.integer(mclass$Factor),
gg_K = as.integer(prinit$Gparmi["K1"]),
gg_gamma = as.double(gspline.bar["gamma1"]),
gg_delta = as.double(gspline.bar["delta1"]),
gg_sigma = as.double(sqrt(gspline.sigmaSq.bar)),
#gg_sigma = as.double(gspline.bar["sigma1"]),
gg_intcpt = as.double(gspline.bar["intercept1"]),
gg_scale = as.double(sqrt(gspline.scaleSq.bar)),
#gg_scale = as.double(gspline.bar["scale1"]),
gg_w = as.double(mweight.bar),
nP = as.integer(des$n),
PACKAGE = thispackage)
D.in.bar <- -2 * sum(log(inD$iPML))
}
### DIC and log(PML)
pD <- D.bar - D.in.bar
DIC <- D.bar + pD
logPML <- sum(log(fit$iPML))
attr(toreturn, "fitStat") <- c(logPML, DIC, D.bar, D.in.bar, pD)
names(attr(toreturn, "fitStat")) <- c("logPML", "DIC", "D.bar", "D.in.bar", "pD")
attr(toreturn, "iPML") <- fit$iPML
}
class(toreturn) <- "bayessurvreg3"
return(toreturn)
}
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