Nothing
R/helper.R
In bootf2: Simulation and Comparison of Dissolution Profiles
Defines functions
rpt.screen
rpt.intermediate
rpt.info
rpt.detailed
rpt.concise
rpt.f2
rpt.ci
mod.ref
ci.header
bpwhisker.u
bpwhisker.l
Documented in
bpwhisker.l
bpwhisker.u
ci.header
mod.ref
rpt.ci
rpt.concise
rpt.detailed
rpt.f2
rpt.info
rpt.intermediate
rpt.screen
#' Helper Functions
#'
#' @param x Numeric vector
#' @name helper
NULL
# Contents:
## - bpwhisker.l
## - bpwhisker.u
## - ci.header
## - mod.ref
## - rpt.ci
## - rpt.f2
## - rpt.concise
## - rpt.detailed
## - rpt.intermediate
## - rpt.screen
#' @rdname helper
# upper and lower whisker for boxplot
bpwhisker.l <- function(x) {
qt25 <- quantile(x, probs = 0.25, na.rm = TRUE)[[1]]
qt75 <- quantile(x, probs = 0.75, na.rm = TRUE)[[1]]
min(x[x >= qt25 - 1.5*(qt75 - qt25)], na.rm = TRUE)
}
#' @rdname helper
bpwhisker.u <- function(x) {
qt25 <- quantile(x, probs = 0.25, na.rm = TRUE)[[1]]
qt75 <- quantile(x, probs = 0.75, na.rm = TRUE)[[1]]
max(x[x <= qt75 + 1.5*(qt75 - qt25)], na.rm = TRUE)
}
#' @param boot.info A data frame of bootstrap information from `bootf2`
#' function.
#' @rdname helper
ci.header <- function(boot.info) {
# need some trick for print format depending on user set decimal
# for CI type: "%24s", rest "%3s", lower, "%3s", upper
# header ----
if (boot.info$digits <= 2) {
cat(" Types of Lower Upper\n",
" Confidence Intervals <----------->\n", sep = "")
} else {
cat(" Types of Lower", rep(" ", 2*boot.info$digits - 1),
"Upper\n", " Confidence Intervals <----",
rep("-", 2*boot.info$digits - 1), "---->\n", sep = "")
}
}
#' @param tp,ref.dp Numeric vector of time points \code{tp} and their
#' corresponding mean dissolution profiles \code{ref.dp}.
#' @param digits An integer indicating the decimal points for the output.
#' @param model Strings of model names. Currently only 'Weibull' and
#' 'first-order' models are supported.
#' @param max.disso Numeric value indicating the maximum dissolution.
#' @param time.unit Character strings indicating the unit of time. It should
#' be either \code{"min"} for minute or \code{"h"} for hour. It is mainly
#' used for checking CV rules and making plot. @seealso [calcf2()].
#' @rdname helper
mod.ref <- function(tp, ref.dp, digits = 4, model, max.disso, time.unit) {
# add random noise in case mean values comes from simulation
ref.dp <- ref.dp + rnorm(length(ref.dp), sd = 0.01)
fmax.ini <- max(ref.dp) + 1
if (fmax.ini > max.disso) fmax.ini <- max.disso
# 50% of the 1st time points with non-zero dissolution
tlag.ini <- 0.5*tp[ref.dp > 0][[1]]
# for IR dosage form, 5 min not considered as lag time
if (all(time.unit == "min", tlag.ini <= 5)) {
tlag.ini <- 0
}
tp.adj <- tp - tlag.ini
tp.adj[tp.adj < 0] <- 0
tmp1 <- data.frame(tp = tp, ref.dp = ref.dp, tp.adj = tp.adj)
if (model == "first-order") {
mod.ini <- lm(log(1 - ref.dp/fmax.ini) ~ 0 + tp.adj, data = tmp1)
k.ini <- -coef(mod.ini)[[1]]
ctr <- nls.control(maxiter = 500)
mod <- minpack.lm::nlsLM(
ref.dp ~ fmax*(1 - exp(-k*(tp - tlag))), data = tmp1, control = ctr,
start = c(fmax = fmax.ini, tlag = tlag.ini, k = k.ini)
)
# coef(mod)[[2]] --> tlag,
if (any(all(time.unit == "min", coef(mod)[[2]] <= 5),
coef(mod)[[2]] <= 0)) {
mod.par <- data.frame(model = "first-order",
fmax = coef(mod)[[1]], fmax.cv = 5,
tlag = 0, tlag.cv = 0,
k = coef(mod)[[3]], k.cv = 30,
time.unit = time.unit, stringsAsFactors = FALSE)
} else {
mod.par <- data.frame(model = "first-order",
fmax = coef(mod)[[1]], fmax.cv = 5,
tlag = coef(mod)[[2]], tlag.cv = 30,
k = coef(mod)[[3]], k.cv = 30,
time.unit = time.unit, stringsAsFactors = FALSE)
}
# end model first-order
} else if (model == "Weibull") {
# mean dissolution time corresponds 0.63212 F/Fmax
t1 <- max(tmp1[tmp1[, 2] <= 0.63212*fmax.ini, 3])
t2 <- min(tmp1[tmp1[, 2] > 0.63212*fmax.ini, 3])
d1 <- tmp1[tmp1[, 3] == t1, 2]
d2 <- tmp1[tmp1[, 3] == t2, 2]
mdt.ini <- t2 - (t2 - t1)*(d2 - 0.63212*fmax.ini)/(d2 - d1) + tlag.ini
mdt.ini <- ifelse(mdt.ini < t1, t1, mdt.ini)
mod.ini <- lm(log10(-log(1 - ref.dp/fmax.ini)) ~ 0 + log(tp.adj/mdt.ini),
data = tmp1[tmp1[, 3] > 0, ])
beta.ini <- coef(mod.ini)[[1]]
ctr <- nls.control(maxiter = 500)
mod <- minpack.lm::nlsLM(
ref.dp ~ fmax*(1 - exp(-((tp - tlag)/mdt)^beta)),
data = tmp1[tmp1[, 3] > 0, ], control = ctr,
start = c(fmax = fmax.ini, tlag = tlag.ini, mdt = mdt.ini,
beta = beta.ini)
)
if (any(all(time.unit == "min", coef(mod)[[2]] <= 5),
coef(mod)[[2]] <= 0)) {
mod.par <- data.frame(model = "Weibull",
fmax = coef(mod)[[1]], fmax.cv = 5,
tlag = 0, tlag.cv = 0,
mdt = coef(mod)[[3]], mdt.cv = 30,
beta = coef(mod)[[4]], beta.cv = 30,
time.unit = time.unit, stringsAsFactors = FALSE)
} else {
mod.par <- data.frame(model = "Weibull",
fmax = coef(mod)[[1]], fmax.cv = 5,
tlag = coef(mod)[[2]], tlag.cv = 30,
mdt = coef(mod)[[3]], mdt.cv = 30,
beta = coef(mod)[[4]], beta.cv = 30,
time.unit = time.unit, stringsAsFactors = FALSE)
}
}# end Weibull model fitting
return(mod.par)
} # end function mod.ref
#' @param f2type Character strings indicating the f2 type.
#' @param btsum A data frame of descriptive statistics of the bootstrap data
#' set.
#' @rdname helper
rpt.ci <- function(f2type, btsum, boot.info) {
cat("------------------------------------------------------------\n")
cat(" Out of", boot.info$n.boots, "bootstrapped data sets,\n")
cat(" - Number of f2 calculated with 1 time point : ",
btsum[btsum$f2.type == f2type, ]$f2.tp1, "\n", sep = "")
cat(" - Number of f2 calculated with 2 time point : ",
btsum[btsum$f2.type == f2type, ]$f2.tp2, "\n", sep = "")
cat(" - Number of f2 cannot be calculated (NA) : ",
btsum[btsum$f2.type == f2type, ]$boot.na, "\n", sep = "")
cat(" - Number of T and R dissolving more than 85% at 15 min : ",
btsum[btsum$f2.type == f2type, ]$d85at15, "\n", sep = "")
cat("------------------------------------------------------------\n")
if (boot.info$f2.type == "all") {
cat("_____________________________________________________",
"_________________\n\n", sep = "")
} else {
cat("\n\n")
}
}
#' @param f2type Character strings indicating the f2 type.
#' @param f2o Vector of f2 values calculated with the original data set
#' @param a.jack Data frame of acceleration from `jackf2` function
#' @rdname helper
rpt.f2 <- function(f2type, f2o, boot.info, a.jack, btsum) {
cat(" - with original data : ",
round(f2o[[f2type]], boot.info$digits), "\n", sep = "")
if (boot.info$ci.type %in% c("all", "bca.jackknife")) {
for (i in seq_len(NROW(a.jack))) {
cat(" - with original data (by Jackknife, ", a.jack[i, "type"],
") : ", round(a.jack[i, f2type], boot.info$digits), "\n", sep = "")
}
}
cat(" - with bootstrapped data (Mean) : ",
round(btsum[btsum$f2.type == f2type, ]$boot.mean, boot.info$digits),
"\n", sep = "")
cat(" - with bootstrapped data (Median) : ",
round(btsum[btsum$f2.type == f2type, ]$boot.median, boot.info$digits),
"\n\n", sep = "")
cat("-----------------------\n")
cat("* Confidence Intervals\n")
cat("-----------------------\n")
ci.header(boot.info)
}
#' @param boot.f2.ci Matrix of f2 values from bootstrap data sets
#' @rdname helper
rpt.concise <- function(boot.f2.ci, boot.info, f2o, a.jack, btsum) {
rpt.screen(boot.f2.ci, boot.info, f2o, a.jack, btsum)
sysinfo <- Sys.info()
cat("The current report was generated at ",
format(Sys.time(), "%H:%M:%S"), " on ", format(Sys.time(), "%F"),
" ", format(Sys.time(), "%Z"), " by\nuser '", sysinfo["user"],
"' on machine '", sysinfo["nodename"], "', and saved as text file\n'",
boot.info$file.out, "' at the location:\n'", boot.info$path.out, "'.\n",
sep = "")
cat("=============================================================",
"=========\n\n", sep = "")
# end concise report style.
}
#' @param data.t,data.r Input data sets for test and reference.
#' @param boot.t,boot.r List of bootstrap data sets for test and reference.
#' @param boot.f2 Matrix of f2 calculated from bootstrap data sets.
#' @rdname helper
rpt.detailed <- function(data.t, data.r, boot.t, boot.r, boot.f2, boot.info,
f2o) {
cat("\n=====================================================",
"===========================\n\n", sep = "")
cat("Individual bootstrapped data set and its f2s\n")
cat("_______________________________________________________",
"_________________________\n\n", sep = "")
cat("Original data set for test\n--------------------------\n")
print(as.data.frame(data.t), row.names = FALSE)
cat("\nOriginal data set for reference\n")
cat("-------------------------------\n")
print(as.data.frame(data.r), row.names = FALSE)
tpo <- data.r[, 1][data.r[, 1] > 0][1:f2o[["f2.tp"]]]
cat("\n-----------------------------------\n\n")
if (boot.info$f2.type %in% c("all", "est.f2")) {
cat("- Estimated f2 : ", f2o[["est.f2"]],
"\n", sep = "")
}
if (boot.info$f2.type %in% c("all", "exp.f2")) {
cat("- Expected f2 : ", f2o[["exp.f2"]],
"\n", sep = "")
}
if (boot.info$f2.type %in% c("all", "bc.f2")) {
cat("- Bias-corrected f2 : ", f2o[["bc.f2"]],
"\n", sep = "")
}
if (boot.info$f2.type %in% c("all", "vc.exp.f2")) {
cat("- Variance-corrected expected f2 : ", f2o[["vc.exp.f2"]],
"\n", sep = "")
}
if (boot.info$f2.type %in% c("all", "vc.bc.f2")) {
cat("- Variance- and bias-corrected f2 : ", f2o[["vc.bc.f2"]],
"\n", sep = "")
}
cat("- Time Points Used : ", f2o[["f2.tp"]], " (",
paste0(tpo[1:length(tpo) - 1], rep(", ", length(tpo) - 1)), "and ",
tpo[length(tpo)], " ", boot.info$time.unit, ")\n", sep = "")
cat("- T & R dissolved more than 85% at 15 min : ",
ifelse(unique(f2o[["d85at15"]]) == 1, "Yes", "no"), "\n", sep = "")
cat("-------------------------------------------------------",
"-------------------------\n\n\n", sep = "")
for (i in 1:boot.info$n.boots) {
dimnames(boot.t[[i]])[[2]] <-
c("time", paste0("U", 1:(NCOL(boot.t[[i]]) - 1)))
dimnames(boot.r[[i]])[[2]] <-
c("time", paste0("U", 1:(NCOL(boot.r[[i]]) - 1)))
tpb <- boot.t[[i]][, 1][boot.t[[i]][, 1] > 0][1:boot.f2[i, "f2.tp"]]
cat("Bootstrap data set for test : ", i, "\n", sep = "")
cat("-----------------------------------\n")
print(boot.t[[i]], row.names = FALSE)
cat("\n")
cat("Bootstrap data set for reference : ", i, "\n", sep = "")
cat("-----------------------------------\n")
print(boot.r[[i]], row.names = FALSE)
cat("\n-----------------------------------\n\n")
if (boot.info$f2.type %in% c("all", "est.f2")) {
cat("- Estimated f2 : ",
boot.f2[[i, "est.f2"]], "\n", sep = "")
}
if (boot.info$f2.type %in% c("all", "exp.f2")) {
cat("- Expected f2 : ",
boot.f2[[i, "exp.f2"]], "\n", sep = "")
}
if (boot.info$f2.type %in% c("all", "bc.f2")) {
cat("- Bias-corrected f2 : ",
boot.f2[[i, "bc.f2"]], "\n", sep = "")
}
if (boot.info$f2.type %in% c("all", "vc.exp.f2")) {
cat("- Variance-corrected expected f2 : ",
boot.f2[[i, "vc.exp.f2"]], "\n", sep = "")
}
if (boot.info$f2.type %in% c("all", "vc.bc.f2")) {
cat("- Variance- and bias-corrected f2 : ",
boot.f2[[i, "vc.bc.f2"]], "\n", sep = "")
}
cat("- Time Points Used : ",
boot.f2[[i, "f2.tp"]], " (",
paste0(tpb[1:(length(tpb) - 1)], rep(", ", length(tpo) - 1)), "and ",
tpb[length(tpb)], " ", boot.info$time.unit, ")\n", sep = "")
cat("- T & R dissolved more than 85% at 15 min : ",
ifelse(boot.f2[i, "d85at15"] == 1, "Yes", "no"), "\n", sep = "")
cat("-------------------------------------------------------",
"-------------------------\n\n", sep = "")
} # end loop for i data set
cat("\n=====================================================",
"===========================\n\n", sep = "")
}
#' @rdname helper
rpt.info <- function(boot.info) {
# system and program info ----------------------------------------
# output function settings so anyone who read the results can reproduce it
cat("============================================\n")
cat("| Function Settings and System Information |\n")
cat("============================================\n\n")
cat("---------------------\n")
cat("* Function Settings\n")
cat("---------------------\n")
cat(" - test : ", boot.info$test, "\n", sep = "")
cat(" - ref : ", boot.info$ref, "\n", sep = "")
cat(" - n.boots : ", boot.info$n.boots, "\n", sep = "")
cat(" - seed : ", boot.info$seed, "\n", sep = "")
cat(" - digits : ", boot.info$digits, "\n", sep = "")
cat(" - alpha : ", boot.info$alpha, " (",
(1 - 2*boot.info$alpha)*100, "% CI)\n", sep = "")
cat(" - regulation : ", boot.info$regulation, "\n", sep = "")
cat(" - min.points : ", boot.info$min.points, "\n", sep = "")
cat(" - both.TR.85 : ", boot.info$both.TR.85, "\n", sep = "")
cat(" - print.report : ", boot.info$print.report, "\n", sep = "")
cat(" - report.style : ", boot.info$report.style, "\n", sep = "")
cat(" - f2.type : ", boot.info$f2.type, "\n", sep = "")
cat(" - ci.type : ", boot.info$ci.type, "\n", sep = "")
cat(" - quantile.type : ", boot.info$quantile.type, "\n", sep = "")
cat(" - jackknife.type : ", boot.info$jackknife.type, "\n", sep = "")
cat(" - time.unit : ", boot.info$time.unit, "\n", sep = "")
cat(" - output.to.screen : ", boot.info$output.to.screen, "\n", sep = "")
cat(" - sim.data.out : ", boot.info$sim.data.out, "\n", sep = "")
cat(" - path.in : ", boot.info$path.in, "\n", sep = "")
cat(" - file.in : ", boot.info$file.in, "\n", sep = "")
cat(" - path.out : ", boot.info$path.out, "\n", sep = "")
cat(" - file.out : ", boot.info$file.out, "\n\n", sep = "")
cat("---------------------\n")
cat("* System Information\n")
cat("---------------------\n")
sysinfo0 <- sessionInfo()
rinfo <- strsplit(sessionInfo()$R.version$version.string, " ")
sysinfo1 <- Sys.info()
bootf2v <- as.character(packageVersion("bootf2"))
cat(" - OS Platform : ", sysinfo0$platform, "\n", sep = "")
cat(" - OS Name and Release : ", sysinfo0$running, "\n", sep = "")
cat(" - Machine Node Name : ",
sysinfo1["nodename"], "\n", sep = "")
cat(" - User Name : ",
sysinfo1["user"], "\n", sep = "")
cat(" - Time Zone : ",
Sys.timezone(), "\n", sep = "")
cat(" - R Version : ",
rinfo[[1]][3], " ", rinfo[[1]][4], "\n", sep = "")
cat(" - Package bootf2 Version : ", bootf2v, "\n", sep = "")
cat("_____________________________________________________",
"_________________\n\n", sep = "")
}# end function rpt.info
#' @rdname helper
rpt.intermediate <- function(boot.info, boot.f2) {
cat("Individual f2 for each bootstrapped data set\n")
cat("___________________________________________________________",
"___________\n\n", sep = "")
if (boot.info$f2.type == "all") {
if (boot.info$digits <= 2) {
cat("Bootstrap est.f2 exp.f2 bc.f2 vc.exp.f2 vc.bc.f2 ",
"f2.tp TR>85%\n", sep = "")
for (i in 1:boot.info$n.boots) {
cat(sprintf(paste0("%2s", "%-7s", "%2s",
paste0("%-6", ".", boot.info$digits, "f"), "%2s",
paste0("%-6", ".", boot.info$digits, "f"), "%2s",
paste0("%-6", ".", boot.info$digits, "f"), "%2s",
paste0("%-9", ".", boot.info$digits, "f"), "%2s",
paste0("%-8", ".", boot.info$digits, "f"), "%2s",
"%-9s", "%-9s"),
"", i, "", boot.f2[i, 1], "", boot.f2[i, 2], "",
boot.f2[i, 3], "", boot.f2[i, 4], "", boot.f2[i, 5],
"", boot.f2[i, 6], boot.f2[i, 7]),
"\n", sep = "")
}
} else { # digits > 2
cat("Bootstrap est.f2", rep(" ", boot.info$digits - 1), "exp.f2",
rep(" ", boot.info$digits - 1), "bc.f2 ",
rep(" ", boot.info$digits - 1), "vc.exp.f2",
rep(" ", boot.info$digits - 1), "vc.bc.f2",
rep(" ", boot.info$digits - 1), "f2.tp TR>85%\n", sep = "")
for (i in 1:boot.info$n.boots) {
cat(sprintf(paste0("%2s", "%-7s", "%2s",
paste0("%-", boot.info$digits + 3, ".",
boot.info$digits, "f"), "%2s",
paste0("%-", boot.info$digits + 3, ".",
boot.info$digits, "f"), "%2s",
paste0("%-", boot.info$digits + 3, ".",
boot.info$digits, "f"), "%2s",
paste0("%-", boot.info$digits + 6, ".",
boot.info$digits, "f"), "%2s",
paste0("%-", boot.info$digits+5, ".",
boot.info$digits, "f"), "%2s",
"%-9s", "%-9s"), "", i, "",
boot.f2[i, 1], "", boot.f2[i, 2], "", boot.f2[i, 3], "",
boot.f2[i, 4], "", boot.f2[i, 5], "", boot.f2[i, 6],
boot.f2[i, 7]), "\n", sep = "")
}
} # end digits > 2
} else { # f2.type individual
cat("Bootstrap No. ", boot.info$f2.type,
rep(" ", boot.info$digits + 13 - nchar(boot.info$f2.type)),
"f2.tp TR>85%\n", sep = "")
for (i in 1:boot.info$n.boots) {
cat(sprintf(paste0("%4s", "%-9s", "%3s",
paste0("%-", boot.info$digits + 13, ".",
boot.info$digits, "f"), "%-9s", "%-9s"),
"", i, "", boot.f2[i, 1], boot.f2[i, 2], boot.f2[i, 3]),
"\n", sep = "")
}
} # end f2.type
cat("___________________________________________________________",
"___________\n\n", sep = "")
}
#' @rdname helper
rpt.screen <- function(boot.f2.ci, boot.info, f2o, a.jack, btsum) {
# header information. for all styles -----------------------------
cat("=================================================================\n")
cat("| |\n")
cat("| Comparison of Dissolution Profiles by Bootstrap f2 Method. |\n")
cat("|_______________________________________________________________|\n")
cat("| |\n")
cat("| Smimilarity Criterion: |\n")
cat("| ---------------------- |\n")
cat("| To conclude similarity, the lower limit of 90% confidence |\n")
cat("| interval should be greater than or equal to 50. |\n")
cat("| |\n")
cat("=================================================================\n\n")
cat("=================================================================\n")
cat("* T & R dissolved more than 85% at 15 min in original data : ",
ifelse(f2o[["d85at15"]] == 1, "YES|", "NO |"), "\n", sep = "")
cat("=================================================================\n\n")
# f2 and confidence intervals ------------------------------------
cat("============================================\n")
cat("| Main Results: |\n")
cat("| f2 and Its Confidence Intervals (CI)s |\n")
cat("============================================\n\n")
# width for numeric values of ci
cilo <- if (boot.info$digits <= 2) {
paste0("%-5", ".", boot.info$digits, "f")
} else {
paste0("%-", boot.info$digits + 3, ".", boot.info$digits, "f")
}
ciup <- if (boot.info$digits <= 2) {
paste0("%5", ".", boot.info$digits, "f")
} else {
paste0("%", boot.info$digits + 3, ".", boot.info$digits, "f")
}
# for estimated f2 ------------------------------------------
if (boot.info$f2.type %in% c("all", "est.f2")) {
ci.estf2 <- boot.f2.ci[boot.f2.ci[["f2.type"]] == "est.f2", ]
ci.estf2.n <- NROW(ci.estf2)
cat("-------------------------------\n")
cat("* Estimated f2 Values (est.f2)\n")
cat("-------------------------------\n")
rpt.f2("est.f2", f2o, boot.info, a.jack, btsum)
for (i in 1:ci.estf2.n) {
cat(sprintf(paste0("%24s", "%3s", cilo, "%3s", ciup),
ci.estf2[i, 2], "", ci.estf2[i, 3], "", ci.estf2[i, 4]),
"\n", sep = "")
}
rpt.ci("est.f2", btsum, boot.info)
} # end est.f2
# for expected f2 -------------------------------------------
if (boot.info$f2.type %in% c("all", "exp.f2")) {
ci.expf2 <- boot.f2.ci[boot.f2.ci[["f2.type"]] == "exp.f2", ]
ci.expf2.n <- NROW(ci.expf2)
cat("------------------------------\n")
cat("* Expected f2 Values (exp.f2)\n")
cat("------------------------------\n")
rpt.f2("exp.f2",f2o, boot.info, a.jack, btsum)
for (i in 1:ci.expf2.n) {
cat(sprintf(paste0("%24s", "%3s", cilo, "%3s", ciup),
ci.expf2[i, 2], "", ci.expf2[i, 3], "", ci.expf2[i, 4]),
"\n", sep = "")
}
rpt.ci("exp.f2", btsum, boot.info)
} # end exp.f2
# for bias-corrected f2 -------------------------------------
if (boot.info$f2.type %in% c("all", "bc.f2")) {
ci.bcf2 <- boot.f2.ci[boot.f2.ci[["f2.type"]] == "bc.f2", ]
ci.bcf2.n <- NROW(ci.bcf2)
cat("-----------------------------------\n")
cat("* Bias-Corrected f2 Values (bc.f2)\n")
cat("-----------------------------------\n")
rpt.f2("bc.f2", f2o, boot.info, a.jack, btsum)
for (i in 1:ci.bcf2.n) {
cat(sprintf(paste0("%24s", "%3s", cilo, "%3s", ciup),
ci.bcf2[i, 2], "", ci.bcf2[i, 3], "", ci.bcf2[i, 4]),
"\n", sep = "")
}
rpt.ci("bc.f2", btsum, boot.info)
} # end bc.f2
# for variance corrected expected f2 ------------------------
if (boot.info$f2.type %in% c("all", "vc.exp.f2")) {
ci.vcexpf2 <- boot.f2.ci[boot.f2.ci[["f2.type"]] == "vc.exp.f2", ]
ci.vcexpf2.n <- NROW(ci.vcexpf2)
cat("----------------------------------------------------\n")
cat("* Variance-corrected Expected f2 Values (vc.exp.f2)\n")
cat("----------------------------------------------------\n")
rpt.f2("vc.exp.f2", f2o, boot.info, a.jack, btsum)
for (i in 1:ci.vcexpf2.n) {
cat(sprintf(paste0("%24s", "%3s", cilo, "%3s", ciup), ci.vcexpf2[i, 2],
"", ci.vcexpf2[i, 3], "", ci.vcexpf2[i, 4]),
"\n", sep = "")
}
rpt.ci("vc.exp.f2", btsum, boot.info)
} # end vc.exp.f2
# for variance- and bias-corrected f2 -----------------------
if (boot.info$f2.type %in% c("all", "vc.bc.f2")) {
ci.vcbcf2 <- boot.f2.ci[boot.f2.ci[["f2.type"]] == "vc.bc.f2", ]
ci.vcbcf2.n <- NROW(ci.vcbcf2)
cat("----------------------------------------------------\n")
cat("* Variance- and Bias-Corrected f2 Values (vc.bc.f2)\n")
cat("----------------------------------------------------\n")
rpt.f2("vc.bc.f2", f2o, boot.info, a.jack, btsum)
for (i in 1:ci.vcbcf2.n) {
cat(sprintf(paste0("%24s", "%3s", cilo, "%3s", ciup),
ci.vcbcf2[i, 2], "", ci.vcbcf2[i, 3], "", ci.vcbcf2[i, 4]),
"\n", sep = "")
}
rpt.ci("vc.bc.f2", btsum, boot.info)
} # end vc.bc.f2
rpt.info(boot.info)
}# end rpt.screen function
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Defines functions rpt.screen rpt.intermediate rpt.info rpt.detailed rpt.concise rpt.f2 rpt.ci mod.ref ci.header bpwhisker.u bpwhisker.l
Documented in bpwhisker.l bpwhisker.u ci.header mod.ref rpt.ci rpt.concise rpt.detailed rpt.f2 rpt.info rpt.intermediate rpt.screen
#' Helper Functions
#'
#' @param x Numeric vector
#' @name helper
NULL
# Contents:
## - bpwhisker.l
## - bpwhisker.u
## - ci.header
## - mod.ref
## - rpt.ci
## - rpt.f2
## - rpt.concise
## - rpt.detailed
## - rpt.intermediate
## - rpt.screen
#' @rdname helper
# upper and lower whisker for boxplot
bpwhisker.l <- function(x) {
qt25 <- quantile(x, probs = 0.25, na.rm = TRUE)[[1]]
qt75 <- quantile(x, probs = 0.75, na.rm = TRUE)[[1]]
min(x[x >= qt25 - 1.5*(qt75 - qt25)], na.rm = TRUE)
}
#' @rdname helper
bpwhisker.u <- function(x) {
qt25 <- quantile(x, probs = 0.25, na.rm = TRUE)[[1]]
qt75 <- quantile(x, probs = 0.75, na.rm = TRUE)[[1]]
max(x[x <= qt75 + 1.5*(qt75 - qt25)], na.rm = TRUE)
}
#' @param boot.info A data frame of bootstrap information from `bootf2`
#' function.
#' @rdname helper
ci.header <- function(boot.info) {
# need some trick for print format depending on user set decimal
# for CI type: "%24s", rest "%3s", lower, "%3s", upper
# header ----
if (boot.info$digits <= 2) {
cat(" Types of Lower Upper\n",
" Confidence Intervals <----------->\n", sep = "")
} else {
cat(" Types of Lower", rep(" ", 2*boot.info$digits - 1),
"Upper\n", " Confidence Intervals <----",
rep("-", 2*boot.info$digits - 1), "---->\n", sep = "")
}
}
#' @param tp,ref.dp Numeric vector of time points \code{tp} and their
#' corresponding mean dissolution profiles \code{ref.dp}.
#' @param digits An integer indicating the decimal points for the output.
#' @param model Strings of model names. Currently only 'Weibull' and
#' 'first-order' models are supported.
#' @param max.disso Numeric value indicating the maximum dissolution.
#' @param time.unit Character strings indicating the unit of time. It should
#' be either \code{"min"} for minute or \code{"h"} for hour. It is mainly
#' used for checking CV rules and making plot. @seealso [calcf2()].
#' @rdname helper
mod.ref <- function(tp, ref.dp, digits = 4, model, max.disso, time.unit) {
# add random noise in case mean values comes from simulation
ref.dp <- ref.dp + rnorm(length(ref.dp), sd = 0.01)
fmax.ini <- max(ref.dp) + 1
if (fmax.ini > max.disso) fmax.ini <- max.disso
# 50% of the 1st time points with non-zero dissolution
tlag.ini <- 0.5*tp[ref.dp > 0][[1]]
# for IR dosage form, 5 min not considered as lag time
if (all(time.unit == "min", tlag.ini <= 5)) {
tlag.ini <- 0
}
tp.adj <- tp - tlag.ini
tp.adj[tp.adj < 0] <- 0
tmp1 <- data.frame(tp = tp, ref.dp = ref.dp, tp.adj = tp.adj)
if (model == "first-order") {
mod.ini <- lm(log(1 - ref.dp/fmax.ini) ~ 0 + tp.adj, data = tmp1)
k.ini <- -coef(mod.ini)[[1]]
ctr <- nls.control(maxiter = 500)
mod <- minpack.lm::nlsLM(
ref.dp ~ fmax*(1 - exp(-k*(tp - tlag))), data = tmp1, control = ctr,
start = c(fmax = fmax.ini, tlag = tlag.ini, k = k.ini)
)
# coef(mod)[[2]] --> tlag,
if (any(all(time.unit == "min", coef(mod)[[2]] <= 5),
coef(mod)[[2]] <= 0)) {
mod.par <- data.frame(model = "first-order",
fmax = coef(mod)[[1]], fmax.cv = 5,
tlag = 0, tlag.cv = 0,
k = coef(mod)[[3]], k.cv = 30,
time.unit = time.unit, stringsAsFactors = FALSE)
} else {
mod.par <- data.frame(model = "first-order",
fmax = coef(mod)[[1]], fmax.cv = 5,
tlag = coef(mod)[[2]], tlag.cv = 30,
k = coef(mod)[[3]], k.cv = 30,
time.unit = time.unit, stringsAsFactors = FALSE)
}
# end model first-order
} else if (model == "Weibull") {
# mean dissolution time corresponds 0.63212 F/Fmax
t1 <- max(tmp1[tmp1[, 2] <= 0.63212*fmax.ini, 3])
t2 <- min(tmp1[tmp1[, 2] > 0.63212*fmax.ini, 3])
d1 <- tmp1[tmp1[, 3] == t1, 2]
d2 <- tmp1[tmp1[, 3] == t2, 2]
mdt.ini <- t2 - (t2 - t1)*(d2 - 0.63212*fmax.ini)/(d2 - d1) + tlag.ini
mdt.ini <- ifelse(mdt.ini < t1, t1, mdt.ini)
mod.ini <- lm(log10(-log(1 - ref.dp/fmax.ini)) ~ 0 + log(tp.adj/mdt.ini),
data = tmp1[tmp1[, 3] > 0, ])
beta.ini <- coef(mod.ini)[[1]]
ctr <- nls.control(maxiter = 500)
mod <- minpack.lm::nlsLM(
ref.dp ~ fmax*(1 - exp(-((tp - tlag)/mdt)^beta)),
data = tmp1[tmp1[, 3] > 0, ], control = ctr,
start = c(fmax = fmax.ini, tlag = tlag.ini, mdt = mdt.ini,
beta = beta.ini)
)
if (any(all(time.unit == "min", coef(mod)[[2]] <= 5),
coef(mod)[[2]] <= 0)) {
mod.par <- data.frame(model = "Weibull",
fmax = coef(mod)[[1]], fmax.cv = 5,
tlag = 0, tlag.cv = 0,
mdt = coef(mod)[[3]], mdt.cv = 30,
beta = coef(mod)[[4]], beta.cv = 30,
time.unit = time.unit, stringsAsFactors = FALSE)
} else {
mod.par <- data.frame(model = "Weibull",
fmax = coef(mod)[[1]], fmax.cv = 5,
tlag = coef(mod)[[2]], tlag.cv = 30,
mdt = coef(mod)[[3]], mdt.cv = 30,
beta = coef(mod)[[4]], beta.cv = 30,
time.unit = time.unit, stringsAsFactors = FALSE)
}
}# end Weibull model fitting
return(mod.par)
} # end function mod.ref
#' @param f2type Character strings indicating the f2 type.
#' @param btsum A data frame of descriptive statistics of the bootstrap data
#' set.
#' @rdname helper
rpt.ci <- function(f2type, btsum, boot.info) {
cat("------------------------------------------------------------\n")
cat(" Out of", boot.info$n.boots, "bootstrapped data sets,\n")
cat(" - Number of f2 calculated with 1 time point : ",
btsum[btsum$f2.type == f2type, ]$f2.tp1, "\n", sep = "")
cat(" - Number of f2 calculated with 2 time point : ",
btsum[btsum$f2.type == f2type, ]$f2.tp2, "\n", sep = "")
cat(" - Number of f2 cannot be calculated (NA) : ",
btsum[btsum$f2.type == f2type, ]$boot.na, "\n", sep = "")
cat(" - Number of T and R dissolving more than 85% at 15 min : ",
btsum[btsum$f2.type == f2type, ]$d85at15, "\n", sep = "")
cat("------------------------------------------------------------\n")
if (boot.info$f2.type == "all") {
cat("_____________________________________________________",
"_________________\n\n", sep = "")
} else {
cat("\n\n")
}
}
#' @param f2type Character strings indicating the f2 type.
#' @param f2o Vector of f2 values calculated with the original data set
#' @param a.jack Data frame of acceleration from `jackf2` function
#' @rdname helper
rpt.f2 <- function(f2type, f2o, boot.info, a.jack, btsum) {
cat(" - with original data : ",
round(f2o[[f2type]], boot.info$digits), "\n", sep = "")
if (boot.info$ci.type %in% c("all", "bca.jackknife")) {
for (i in seq_len(NROW(a.jack))) {
cat(" - with original data (by Jackknife, ", a.jack[i, "type"],
") : ", round(a.jack[i, f2type], boot.info$digits), "\n", sep = "")
}
}
cat(" - with bootstrapped data (Mean) : ",
round(btsum[btsum$f2.type == f2type, ]$boot.mean, boot.info$digits),
"\n", sep = "")
cat(" - with bootstrapped data (Median) : ",
round(btsum[btsum$f2.type == f2type, ]$boot.median, boot.info$digits),
"\n\n", sep = "")
cat("-----------------------\n")
cat("* Confidence Intervals\n")
cat("-----------------------\n")
ci.header(boot.info)
}
#' @param boot.f2.ci Matrix of f2 values from bootstrap data sets
#' @rdname helper
rpt.concise <- function(boot.f2.ci, boot.info, f2o, a.jack, btsum) {
rpt.screen(boot.f2.ci, boot.info, f2o, a.jack, btsum)
sysinfo <- Sys.info()
cat("The current report was generated at ",
format(Sys.time(), "%H:%M:%S"), " on ", format(Sys.time(), "%F"),
" ", format(Sys.time(), "%Z"), " by\nuser '", sysinfo["user"],
"' on machine '", sysinfo["nodename"], "', and saved as text file\n'",
boot.info$file.out, "' at the location:\n'", boot.info$path.out, "'.\n",
sep = "")
cat("=============================================================",
"=========\n\n", sep = "")
# end concise report style.
}
#' @param data.t,data.r Input data sets for test and reference.
#' @param boot.t,boot.r List of bootstrap data sets for test and reference.
#' @param boot.f2 Matrix of f2 calculated from bootstrap data sets.
#' @rdname helper
rpt.detailed <- function(data.t, data.r, boot.t, boot.r, boot.f2, boot.info,
f2o) {
cat("\n=====================================================",
"===========================\n\n", sep = "")
cat("Individual bootstrapped data set and its f2s\n")
cat("_______________________________________________________",
"_________________________\n\n", sep = "")
cat("Original data set for test\n--------------------------\n")
print(as.data.frame(data.t), row.names = FALSE)
cat("\nOriginal data set for reference\n")
cat("-------------------------------\n")
print(as.data.frame(data.r), row.names = FALSE)
tpo <- data.r[, 1][data.r[, 1] > 0][1:f2o[["f2.tp"]]]
cat("\n-----------------------------------\n\n")
if (boot.info$f2.type %in% c("all", "est.f2")) {
cat("- Estimated f2 : ", f2o[["est.f2"]],
"\n", sep = "")
}
if (boot.info$f2.type %in% c("all", "exp.f2")) {
cat("- Expected f2 : ", f2o[["exp.f2"]],
"\n", sep = "")
}
if (boot.info$f2.type %in% c("all", "bc.f2")) {
cat("- Bias-corrected f2 : ", f2o[["bc.f2"]],
"\n", sep = "")
}
if (boot.info$f2.type %in% c("all", "vc.exp.f2")) {
cat("- Variance-corrected expected f2 : ", f2o[["vc.exp.f2"]],
"\n", sep = "")
}
if (boot.info$f2.type %in% c("all", "vc.bc.f2")) {
cat("- Variance- and bias-corrected f2 : ", f2o[["vc.bc.f2"]],
"\n", sep = "")
}
cat("- Time Points Used : ", f2o[["f2.tp"]], " (",
paste0(tpo[1:length(tpo) - 1], rep(", ", length(tpo) - 1)), "and ",
tpo[length(tpo)], " ", boot.info$time.unit, ")\n", sep = "")
cat("- T & R dissolved more than 85% at 15 min : ",
ifelse(unique(f2o[["d85at15"]]) == 1, "Yes", "no"), "\n", sep = "")
cat("-------------------------------------------------------",
"-------------------------\n\n\n", sep = "")
for (i in 1:boot.info$n.boots) {
dimnames(boot.t[[i]])[[2]] <-
c("time", paste0("U", 1:(NCOL(boot.t[[i]]) - 1)))
dimnames(boot.r[[i]])[[2]] <-
c("time", paste0("U", 1:(NCOL(boot.r[[i]]) - 1)))
tpb <- boot.t[[i]][, 1][boot.t[[i]][, 1] > 0][1:boot.f2[i, "f2.tp"]]
cat("Bootstrap data set for test : ", i, "\n", sep = "")
cat("-----------------------------------\n")
print(boot.t[[i]], row.names = FALSE)
cat("\n")
cat("Bootstrap data set for reference : ", i, "\n", sep = "")
cat("-----------------------------------\n")
print(boot.r[[i]], row.names = FALSE)
cat("\n-----------------------------------\n\n")
if (boot.info$f2.type %in% c("all", "est.f2")) {
cat("- Estimated f2 : ",
boot.f2[[i, "est.f2"]], "\n", sep = "")
}
if (boot.info$f2.type %in% c("all", "exp.f2")) {
cat("- Expected f2 : ",
boot.f2[[i, "exp.f2"]], "\n", sep = "")
}
if (boot.info$f2.type %in% c("all", "bc.f2")) {
cat("- Bias-corrected f2 : ",
boot.f2[[i, "bc.f2"]], "\n", sep = "")
}
if (boot.info$f2.type %in% c("all", "vc.exp.f2")) {
cat("- Variance-corrected expected f2 : ",
boot.f2[[i, "vc.exp.f2"]], "\n", sep = "")
}
if (boot.info$f2.type %in% c("all", "vc.bc.f2")) {
cat("- Variance- and bias-corrected f2 : ",
boot.f2[[i, "vc.bc.f2"]], "\n", sep = "")
}
cat("- Time Points Used : ",
boot.f2[[i, "f2.tp"]], " (",
paste0(tpb[1:(length(tpb) - 1)], rep(", ", length(tpo) - 1)), "and ",
tpb[length(tpb)], " ", boot.info$time.unit, ")\n", sep = "")
cat("- T & R dissolved more than 85% at 15 min : ",
ifelse(boot.f2[i, "d85at15"] == 1, "Yes", "no"), "\n", sep = "")
cat("-------------------------------------------------------",
"-------------------------\n\n", sep = "")
} # end loop for i data set
cat("\n=====================================================",
"===========================\n\n", sep = "")
}
#' @rdname helper
rpt.info <- function(boot.info) {
# system and program info ----------------------------------------
# output function settings so anyone who read the results can reproduce it
cat("============================================\n")
cat("| Function Settings and System Information |\n")
cat("============================================\n\n")
cat("---------------------\n")
cat("* Function Settings\n")
cat("---------------------\n")
cat(" - test : ", boot.info$test, "\n", sep = "")
cat(" - ref : ", boot.info$ref, "\n", sep = "")
cat(" - n.boots : ", boot.info$n.boots, "\n", sep = "")
cat(" - seed : ", boot.info$seed, "\n", sep = "")
cat(" - digits : ", boot.info$digits, "\n", sep = "")
cat(" - alpha : ", boot.info$alpha, " (",
(1 - 2*boot.info$alpha)*100, "% CI)\n", sep = "")
cat(" - regulation : ", boot.info$regulation, "\n", sep = "")
cat(" - min.points : ", boot.info$min.points, "\n", sep = "")
cat(" - both.TR.85 : ", boot.info$both.TR.85, "\n", sep = "")
cat(" - print.report : ", boot.info$print.report, "\n", sep = "")
cat(" - report.style : ", boot.info$report.style, "\n", sep = "")
cat(" - f2.type : ", boot.info$f2.type, "\n", sep = "")
cat(" - ci.type : ", boot.info$ci.type, "\n", sep = "")
cat(" - quantile.type : ", boot.info$quantile.type, "\n", sep = "")
cat(" - jackknife.type : ", boot.info$jackknife.type, "\n", sep = "")
cat(" - time.unit : ", boot.info$time.unit, "\n", sep = "")
cat(" - output.to.screen : ", boot.info$output.to.screen, "\n", sep = "")
cat(" - sim.data.out : ", boot.info$sim.data.out, "\n", sep = "")
cat(" - path.in : ", boot.info$path.in, "\n", sep = "")
cat(" - file.in : ", boot.info$file.in, "\n", sep = "")
cat(" - path.out : ", boot.info$path.out, "\n", sep = "")
cat(" - file.out : ", boot.info$file.out, "\n\n", sep = "")
cat("---------------------\n")
cat("* System Information\n")
cat("---------------------\n")
sysinfo0 <- sessionInfo()
rinfo <- strsplit(sessionInfo()$R.version$version.string, " ")
sysinfo1 <- Sys.info()
bootf2v <- as.character(packageVersion("bootf2"))
cat(" - OS Platform : ", sysinfo0$platform, "\n", sep = "")
cat(" - OS Name and Release : ", sysinfo0$running, "\n", sep = "")
cat(" - Machine Node Name : ",
sysinfo1["nodename"], "\n", sep = "")
cat(" - User Name : ",
sysinfo1["user"], "\n", sep = "")
cat(" - Time Zone : ",
Sys.timezone(), "\n", sep = "")
cat(" - R Version : ",
rinfo[[1]][3], " ", rinfo[[1]][4], "\n", sep = "")
cat(" - Package bootf2 Version : ", bootf2v, "\n", sep = "")
cat("_____________________________________________________",
"_________________\n\n", sep = "")
}# end function rpt.info
#' @rdname helper
rpt.intermediate <- function(boot.info, boot.f2) {
cat("Individual f2 for each bootstrapped data set\n")
cat("___________________________________________________________",
"___________\n\n", sep = "")
if (boot.info$f2.type == "all") {
if (boot.info$digits <= 2) {
cat("Bootstrap est.f2 exp.f2 bc.f2 vc.exp.f2 vc.bc.f2 ",
"f2.tp TR>85%\n", sep = "")
for (i in 1:boot.info$n.boots) {
cat(sprintf(paste0("%2s", "%-7s", "%2s",
paste0("%-6", ".", boot.info$digits, "f"), "%2s",
paste0("%-6", ".", boot.info$digits, "f"), "%2s",
paste0("%-6", ".", boot.info$digits, "f"), "%2s",
paste0("%-9", ".", boot.info$digits, "f"), "%2s",
paste0("%-8", ".", boot.info$digits, "f"), "%2s",
"%-9s", "%-9s"),
"", i, "", boot.f2[i, 1], "", boot.f2[i, 2], "",
boot.f2[i, 3], "", boot.f2[i, 4], "", boot.f2[i, 5],
"", boot.f2[i, 6], boot.f2[i, 7]),
"\n", sep = "")
}
} else { # digits > 2
cat("Bootstrap est.f2", rep(" ", boot.info$digits - 1), "exp.f2",
rep(" ", boot.info$digits - 1), "bc.f2 ",
rep(" ", boot.info$digits - 1), "vc.exp.f2",
rep(" ", boot.info$digits - 1), "vc.bc.f2",
rep(" ", boot.info$digits - 1), "f2.tp TR>85%\n", sep = "")
for (i in 1:boot.info$n.boots) {
cat(sprintf(paste0("%2s", "%-7s", "%2s",
paste0("%-", boot.info$digits + 3, ".",
boot.info$digits, "f"), "%2s",
paste0("%-", boot.info$digits + 3, ".",
boot.info$digits, "f"), "%2s",
paste0("%-", boot.info$digits + 3, ".",
boot.info$digits, "f"), "%2s",
paste0("%-", boot.info$digits + 6, ".",
boot.info$digits, "f"), "%2s",
paste0("%-", boot.info$digits+5, ".",
boot.info$digits, "f"), "%2s",
"%-9s", "%-9s"), "", i, "",
boot.f2[i, 1], "", boot.f2[i, 2], "", boot.f2[i, 3], "",
boot.f2[i, 4], "", boot.f2[i, 5], "", boot.f2[i, 6],
boot.f2[i, 7]), "\n", sep = "")
}
} # end digits > 2
} else { # f2.type individual
cat("Bootstrap No. ", boot.info$f2.type,
rep(" ", boot.info$digits + 13 - nchar(boot.info$f2.type)),
"f2.tp TR>85%\n", sep = "")
for (i in 1:boot.info$n.boots) {
cat(sprintf(paste0("%4s", "%-9s", "%3s",
paste0("%-", boot.info$digits + 13, ".",
boot.info$digits, "f"), "%-9s", "%-9s"),
"", i, "", boot.f2[i, 1], boot.f2[i, 2], boot.f2[i, 3]),
"\n", sep = "")
}
} # end f2.type
cat("___________________________________________________________",
"___________\n\n", sep = "")
}
#' @rdname helper
rpt.screen <- function(boot.f2.ci, boot.info, f2o, a.jack, btsum) {
# header information. for all styles -----------------------------
cat("=================================================================\n")
cat("| |\n")
cat("| Comparison of Dissolution Profiles by Bootstrap f2 Method. |\n")
cat("|_______________________________________________________________|\n")
cat("| |\n")
cat("| Smimilarity Criterion: |\n")
cat("| ---------------------- |\n")
cat("| To conclude similarity, the lower limit of 90% confidence |\n")
cat("| interval should be greater than or equal to 50. |\n")
cat("| |\n")
cat("=================================================================\n\n")
cat("=================================================================\n")
cat("* T & R dissolved more than 85% at 15 min in original data : ",
ifelse(f2o[["d85at15"]] == 1, "YES|", "NO |"), "\n", sep = "")
cat("=================================================================\n\n")
# f2 and confidence intervals ------------------------------------
cat("============================================\n")
cat("| Main Results: |\n")
cat("| f2 and Its Confidence Intervals (CI)s |\n")
cat("============================================\n\n")
# width for numeric values of ci
cilo <- if (boot.info$digits <= 2) {
paste0("%-5", ".", boot.info$digits, "f")
} else {
paste0("%-", boot.info$digits + 3, ".", boot.info$digits, "f")
}
ciup <- if (boot.info$digits <= 2) {
paste0("%5", ".", boot.info$digits, "f")
} else {
paste0("%", boot.info$digits + 3, ".", boot.info$digits, "f")
}
# for estimated f2 ------------------------------------------
if (boot.info$f2.type %in% c("all", "est.f2")) {
ci.estf2 <- boot.f2.ci[boot.f2.ci[["f2.type"]] == "est.f2", ]
ci.estf2.n <- NROW(ci.estf2)
cat("-------------------------------\n")
cat("* Estimated f2 Values (est.f2)\n")
cat("-------------------------------\n")
rpt.f2("est.f2", f2o, boot.info, a.jack, btsum)
for (i in 1:ci.estf2.n) {
cat(sprintf(paste0("%24s", "%3s", cilo, "%3s", ciup),
ci.estf2[i, 2], "", ci.estf2[i, 3], "", ci.estf2[i, 4]),
"\n", sep = "")
}
rpt.ci("est.f2", btsum, boot.info)
} # end est.f2
# for expected f2 -------------------------------------------
if (boot.info$f2.type %in% c("all", "exp.f2")) {
ci.expf2 <- boot.f2.ci[boot.f2.ci[["f2.type"]] == "exp.f2", ]
ci.expf2.n <- NROW(ci.expf2)
cat("------------------------------\n")
cat("* Expected f2 Values (exp.f2)\n")
cat("------------------------------\n")
rpt.f2("exp.f2",f2o, boot.info, a.jack, btsum)
for (i in 1:ci.expf2.n) {
cat(sprintf(paste0("%24s", "%3s", cilo, "%3s", ciup),
ci.expf2[i, 2], "", ci.expf2[i, 3], "", ci.expf2[i, 4]),
"\n", sep = "")
}
rpt.ci("exp.f2", btsum, boot.info)
} # end exp.f2
# for bias-corrected f2 -------------------------------------
if (boot.info$f2.type %in% c("all", "bc.f2")) {
ci.bcf2 <- boot.f2.ci[boot.f2.ci[["f2.type"]] == "bc.f2", ]
ci.bcf2.n <- NROW(ci.bcf2)
cat("-----------------------------------\n")
cat("* Bias-Corrected f2 Values (bc.f2)\n")
cat("-----------------------------------\n")
rpt.f2("bc.f2", f2o, boot.info, a.jack, btsum)
for (i in 1:ci.bcf2.n) {
cat(sprintf(paste0("%24s", "%3s", cilo, "%3s", ciup),
ci.bcf2[i, 2], "", ci.bcf2[i, 3], "", ci.bcf2[i, 4]),
"\n", sep = "")
}
rpt.ci("bc.f2", btsum, boot.info)
} # end bc.f2
# for variance corrected expected f2 ------------------------
if (boot.info$f2.type %in% c("all", "vc.exp.f2")) {
ci.vcexpf2 <- boot.f2.ci[boot.f2.ci[["f2.type"]] == "vc.exp.f2", ]
ci.vcexpf2.n <- NROW(ci.vcexpf2)
cat("----------------------------------------------------\n")
cat("* Variance-corrected Expected f2 Values (vc.exp.f2)\n")
cat("----------------------------------------------------\n")
rpt.f2("vc.exp.f2", f2o, boot.info, a.jack, btsum)
for (i in 1:ci.vcexpf2.n) {
cat(sprintf(paste0("%24s", "%3s", cilo, "%3s", ciup), ci.vcexpf2[i, 2],
"", ci.vcexpf2[i, 3], "", ci.vcexpf2[i, 4]),
"\n", sep = "")
}
rpt.ci("vc.exp.f2", btsum, boot.info)
} # end vc.exp.f2
# for variance- and bias-corrected f2 -----------------------
if (boot.info$f2.type %in% c("all", "vc.bc.f2")) {
ci.vcbcf2 <- boot.f2.ci[boot.f2.ci[["f2.type"]] == "vc.bc.f2", ]
ci.vcbcf2.n <- NROW(ci.vcbcf2)
cat("----------------------------------------------------\n")
cat("* Variance- and Bias-Corrected f2 Values (vc.bc.f2)\n")
cat("----------------------------------------------------\n")
rpt.f2("vc.bc.f2", f2o, boot.info, a.jack, btsum)
for (i in 1:ci.vcbcf2.n) {
cat(sprintf(paste0("%24s", "%3s", cilo, "%3s", ciup),
ci.vcbcf2[i, 2], "", ci.vcbcf2[i, 3], "", ci.vcbcf2[i, 4]),
"\n", sep = "")
}
rpt.ci("vc.bc.f2", btsum, boot.info)
} # end vc.bc.f2
rpt.info(boot.info)
}# end rpt.screen function
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