phase1_2_outcomes_to_cohorts: Break a phase I/II outcome string into a list of cohort...

In escalation: A Modular Approach to Dose-Finding Clinical Trials

Break a phase I/II outcome string into a list of cohort parts.

Description

Break a phase I/II outcome string into a list of cohort parts.

Break a phase I/II outcome string into a list of cohort parts.

The outcome string describes the doses given, outcomes observed and the timing of analyses that recommend a dose. The format of the string is described in Brock _et al_. (2017).

The letters E, T, N & B are used to represents patients that experienced (E)fficacy, (T)oxicity, (N)either and (B)oth. These letters are concatenated after numerical dose-levels to convey the outcomes of cohorts of patients. For instance, 2NET represents a cohort of three patients that were treated at dose-level 2, one of whom experienced toxicity only, one that experienced efficacy only, and one that had neither. The results of cohorts are separated by spaces and it is assumed that a dose-finding decision takes place at the end of a cohort. Thus, 2NET 1NN builds on our previous example, where the next cohort of two were treated at dose-level 1 and neither of these patients experienced either event See examples.

Usage

phase1_2_outcomes_to_cohorts(outcomes)

Arguments

outcomes

character string representing the doses given, outcomes observed, and timing of analyses. See Description.

Value

a list with a slot for each cohort. Each cohort slot is itself a list, containing elements: * dose, the integer dose delivered to the cohort; * outcomes, a character string representing the E, T N or B outcomes for the patients in this cohort.

References

Brock, K., Billingham, L., Copland, M., Siddique, S., Sirovica, M., & Yap, C. (2017). Implementing the EffTox dose-finding design in the Matchpoint trial. BMC Medical Research Methodology, 17(1), 112. https://doi.org/10.1186/s12874-017-0381-x

Examples

x = phase1_2_outcomes_to_cohorts('1NEN 2ENT 3TB')
length(x)
x[[1]]$dose
x[[1]]$outcomes
x[[2]]$dose
x[[2]]$outcomes
x[[3]]$dose
x[[3]]$outcomes

escalation documentation built on June 27, 2024, 5:09 p.m.