prob_tox_exceeds: Probability that the toxicity rate exceeds some threshold.

In escalation: A Modular Approach to Dose-Finding Clinical Trials

Probability that the toxicity rate exceeds some threshold.

Description

Get the probability that the toxicity rate at each dose exceeds some threshold.

Get the probability that the efficacy rate at each dose exceeds some threshold.

Usage

prob_tox_exceeds(x, threshold, ...)

prob_eff_exceeds(x, threshold, ...)

Arguments

x	Object of type selector
threshold	Probability that efficacy rate exceeds what?
...	arguments passed to other methods

Value

numerical vector of probabilities

numerical vector of probabilities

Examples

# CRM example
skeleton <- c(0.05, 0.1, 0.25, 0.4, 0.6)
target <- 0.25
outcomes <- '1NNN 2NTN'
fit <- get_dfcrm(skeleton = skeleton, target = target) %>% fit(outcomes)
# What is probability that tox rate at each dose exceeds target by >= 10%?
fit %>% prob_tox_exceeds(threshold = target + 0.1)
efftox_priors <- trialr::efftox_priors
p <- efftox_priors(alpha_mean = -7.9593, alpha_sd = 3.5487,
                   beta_mean = 1.5482, beta_sd = 3.5018,
                   gamma_mean = 0.7367, gamma_sd = 2.5423,
                   zeta_mean = 3.4181, zeta_sd = 2.4406,
                   eta_mean = 0, eta_sd = 0.2,
                   psi_mean = 0, psi_sd = 1)
real_doses = c(1.0, 2.0, 4.0, 6.6, 10.0)
model <- get_trialr_efftox(real_doses = real_doses,
                           efficacy_hurdle = 0.5, toxicity_hurdle = 0.3,
                           p_e = 0.1, p_t = 0.1,
                           eff0 = 0.5, tox1 = 0.65,
                           eff_star = 0.7, tox_star = 0.25,
                           priors = p, iter = 1000, chains = 1, seed = 2020)
x <- model %>% fit('1N 2E 3B')
prob_tox_exceeds(x, threshold = 0.45)

escalation documentation built on June 27, 2024, 5:09 p.m.