stop_at_n: Stop when there are n patients in total.

In escalation: Modular Approach to Dose Finding Clinical Trials

Stop when there are n patients in total.

Description

This function adds a restriction to stop a trial when n patients have been evaluated. It does this by adding together the number of patients treated at all doses and stopping when that total exceeds n.

Dose selectors are designed to be daisy-chained together to achieve different behaviours. This class is a **greedy** selector, meaning that it prioritises its own behaviour over the behaviour of other selectors in the chain. That is, it will advocate stopping when the condition has been met, even if the selectors further up the chain would advocate to keep going. In can be interpreted as an overriding selector. This allows the decision to stop to be executed as soon as it is warranted. Be aware though, that there are other selectors that can be placed after this class that will override the stopping behaviour. See Examples.

Usage

stop_at_n(parent_selector_factory, n)

Arguments

parent_selector_factory	Object of type selector_factory.
n	Stop when there are this many patients.

Value

an object of type selector_factory that can fit a dose-finding model to outcomes.

Examples

skeleton <- c(0.05, 0.1, 0.25, 0.4, 0.6)
target <- 0.25

# Create CRM model that will stop when 15 patients are evaluated:
model1 <- get_dfcrm(skeleton = skeleton, target = target) %>%
  stop_at_n(n = 15)

# With 12 patients, this trial should not stop:
fit1 <- model1 %>% fit('1NNN 2NTN 2TNN 2NNN')
fit1 %>% recommended_dose()
fit1 %>% continue()

# With 15 patients, this trial should stop:
fit2 <- model1 %>% fit('1NNN 2NTN 2TNN 2NNN 2NTT')
fit2 %>% recommended_dose()
fit2 %>% continue()

# The stopping behaviour can be overruled by the order of selectors.
# In model2, demanding 9 at recommended dose will trump stopping at 12:
model2 <- get_dfcrm(skeleton = skeleton, target = target) %>%
  stop_at_n(n = 12) %>%
  demand_n_at_dose(dose = 'recommended', n = 9)

# In model3, stopping at 12 will trump demanding 9 at recommended dose:
model3 <- get_dfcrm(skeleton = skeleton, target = target) %>%
  demand_n_at_dose(dose = 'recommended', n = 9) %>%
  stop_at_n(n = 12)

# This model will continue because 9 have not been seen at recommended dose.
fit3 <- model2 %>% fit('1NNN 2NNN 2NNN 3NNN')
fit3 %>% recommended_dose()
fit3 %>% continue()

# This model will stop because 12 have been seen.
fit4 <- model3 %>% fit('1NNN 2NNN 2NNN 3NNN')
fit4 %>% recommended_dose()
fit4 %>% continue()

# With enough observations though, both models will advise stopping because
# both conditions have been met:
fit5 <- model2 %>% fit('1NNN 2NNN 2NNN 5NNN 5NNN 5NNN')
fit5 %>% recommended_dose()
fit5 %>% continue()

fit6 <- model3 %>% fit('1NNN 2NNN 2NNN 5NNN 5NNN 5NNN')
fit6 %>% recommended_dose()
fit6 %>% continue()

escalation documentation built on May 31, 2023, 6:32 p.m.