metap: Meta-analysis of p values
In gap: Genetic Analysis Package

metap

R Documentation

Meta-analysis of p values

Description

Meta-analysis of p values

Usage

metap(data, N, verbose = "Y", prefixp = "p", prefixn = "n")

Arguments

`data`	data frame.
`N`	Number of studies.
`verbose`	Control of detailed output.
`prefixp`	Prefix of p value, with default value "p".
`prefixn`	Preifx of sample size, with default value "n".

Details

This function is the method of meta-analysis used in the Genetic Investigation of ANThropometric Traits (GIANT) consortium, which is based on normal approximation of p values and weighted by sample sizes from individual studies.

Value

x2 Fisher's chi-squared statistics.
p P values from Fisher's method according to chi-squared distribution with 2*N degree(s) of freedom.
z Combined z value.
p1 One-sided p value.
p2 Two-sided p value.

Author(s)

Jing Hua Zhao

Examples

## Not run: 
s <- data.frame(p1=0.1^rep(8:2,each=7,times=1),n1=rep(32000,49),
                p2=0.1^rep(8:2,each=1,times=7),n2=rep(8000,49))
cbind(s,metap(s,2))

# Speliotes, Elizabeth K., M.D. [ESPELIOTES@PARTNERS.ORG]
# 22-2-2008 MRC-Epid JHZ

np <- 7
p <- 0.1^((np+1):2)
z <- qnorm(1-p/2)
n <- c(32000,8000)
n1 <- n[1]

s1 <- s2 <- vector("numeric")

for (i in 1:np)
{
   a <- z[i]
   for (j in 1:np)
   {
       b <- z[j]
       metaz1 <- (sqrt(n1)*a+sqrt(n[1])*b)/sqrt(n1+n[1])
       metap1 <- pnorm(-abs(metaz1))
       metaz2 <- (sqrt(n1)*a+sqrt(n[2])*b)/sqrt(n1+n[2])
       metap2 <- pnorm(-abs(metaz2))
       k <- (i-1)*np+j
       cat(k,"\t",p[i],"\t",p[j],"\t",metap1,metaz1,"\t",metap2,metaz2,"\n")
       s1[k] <- metap1
       s2[k] <- metap2
  }
}

q <- -log10(sort(p,decreasing=TRUE))
t1 <- matrix(-log10(sort(s1,decreasing=TRUE)),np,np)
t2 <- matrix(-log10(sort(s2,decreasing=TRUE)),np,np)

par(mfrow=c(1,2),bg="white",mar=c(4.2,3.8,0.2,0.2))
persp(q,q,t1)
persp(q,q,t2)

## End(Not run)

gap documentation built on Sept. 11, 2024, 5:36 p.m.