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invitroTKstats: In Vitro Toxicokinetic Data Processing and Analysis Pipeline
A set of tools for processing and analyzing in vitro toxicokinetic measurements in a standardized and reproducible pipeline. The package was developed to perform frequentist and Bayesian estimation on a variety of in vitro toxicokinetic measurements including -- but not limited to -- chemical fraction unbound in the presence of plasma (f_up), intrinsic hepatic clearance (Clint, uL/min/million hepatocytes), and membrane permeability for oral absorption (Caco2). The methods provided by the package were described in Wambaugh et al. (2019) <doi:10.1093/toxsci/kfz205>.
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Package details |
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| Author | John Wambaugh [aut] (ORCID: <https://orcid.org/0000-0002-4024-534X>), Sarah E. Davidson-Fritz [aut, cre] (ORCID: <https://orcid.org/0000-0002-2891-9380>), Lindsay Knupp [ctb], Barbara A. Wetmore [ctb] (ORCID: <https://orcid.org/0000-0002-6878-5348>), Zhao Zhihui [ctb], Chantel Nicolas [ctb] (ORCID: <https://orcid.org/0000-0003-2061-5830>), Anna Kreutz [ctb] (ORCID: <https://orcid.org/0000-0002-7787-0683>), U.S. Federal Government [cph] (Copyright holder of this package) |
| Maintainer | Sarah E. Davidson-Fritz <davidsonfritz.sarah@epa.gov> |
| License | MIT + file LICENSE |
| Version | 0.0.13 |
| URL | https://github.com/USEPA/invitroTKstats |
| Package repository | View on CRAN |
| Installation |
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