clint_L3: Clint Level-3 Example Data set
In invitroTKstats: In Vitro Toxicokinetic Data Processing and Analysis Pipeline

clint_L3

R Documentation

Clint Level-3 Example Data set

Description

Mass Spectrometry measurements of intrinsic hepatic clearance (Clint) for cryopreserved pooled human hepatocytes. Chemicals were per- and poly-fluorinated alkyl substance (PFAS) samples. The experiments were led by Dr.s Marci Smeltz and Barbara Wetmore \insertCitesmeltz2023plasmainvitroTKstats. This data set is a subset of experimental data containing samples for 3 test analytes/compounds.

Usage

clint_L3

Format

A level-3 data.frame with 3 rows and 13 variables:

Compound.Name: Name of the test analyte/compound
DTXSID: DSSTox Substance Identifier (CompTox Chemicals Dashboard - CCD)
Lab.Compound.Name: Compound as described in the laboratory
Calibration: Identifier for mass spectrometry calibration – usually the date
Clint: Intrinsic hepatic clearance
Clint.pValue: p-value of estimated Clint value
Fit: Test nominal concentrations
AIC: Akaike Information Criterion of the linear regression fit
AIC.Null: Akaike Information Criterion of the exponential decay assuming a constant rate of decay
Clint.1: Intrinsic hepatic clearance at 1 uM
Clint.10: Intrinsinc hepatic clearance at 10 uM
AIC.Sat: Akaike Information Criterion of the exponential decay with a saturation probability
Sat.pValue: p-value of exponential decay with a saturation probability