clint_L4: Clint Level-4 Example Data set
In invitroTKstats: In Vitro Toxicokinetic Data Processing and Analysis Pipeline

clint_L4

R Documentation

Clint Level-4 Example Data set

Description

Mass Spectrometry measurements of intrinsic hepatic clearance (Clint) for cryopreserved pooled human hepatocytes. Chemicals were per- and poly-fluorinated alkyl substance (PFAS) samples. The experiments were led by Dr.s Marci Smeltz and Barbara Wetmore \insertCitesmeltz2023plasmainvitroTKstats. This data set is a subset of experimental data containing samples for 3 test analytes/compounds.

Usage

clint_L4

Format

A level-4 data.frame with 3 rows and 12 variables:

Compound.Name: Name of the test analyte/compound
DTXSID: DSSTox Substance Identifier (CompTox Chemicals Dashboard - CCD)
Lab.Compound.Name: Compound as described in the laboratory
Clint.1.Med: Median intrinsic hepatic clearance at 1 uM
Clint.1.Low: 2.5th quantile of intrinsic hepatic clearance at 1 uM
Clint.1.High: 97.5th quantile of intrinsic hepatic clearance at 1 uM
Clint.10.Med: Median of intrinsic hepatic clearance at 10 uM
Clint.10.Low: 2.5th quantile of intrinsic hepatic clearance at 10 uM
Clint.10.High: 97.5th quantile of intrinsic hepatic clearance at 1 uM
Clint.pValue: Probability that a decrease is observed
Sat.pValue: Saturation probability that a lower Clint is observed at a higher concentration
degrades.pValue: Probability of abiotic degradation