PKMODEL: Parse PKMODEL BLOCK data

In mrgsolve: Simulate from ODE-Based Models

Parse PKMODEL BLOCK data

Description

Parse PKMODEL BLOCK data

Usage

PKMODEL(
  ncmt = 1,
  depot = FALSE,
  cmt = NULL,
  trans = pick_trans(ncmt, depot),
  env = list(),
  pos = 1,
  ...
)

Arguments

ncmt	number of compartments; must be 1 (one-compartment, not including a depot dosing compartment) or 2 (two-compartment model, not including a depot dosing compartment)
depot	logical indicating whether to add depot compartment
cmt	compartment names as comma-delimited character
trans	the parameterization for the PK model; must be 1, 2, 4, or 11
env	parse environment
pos	block position number
...	not used

Details

When using $PKMODEL, certain symbols must be defined in the model specification depending on the value of ncmt, depot and trans.

• ncmt 1, depot FALSE, trans 2: CL, V

• ncmt 1, depot TRUE , trans 2: CL, V, KA

• ncmt 2, depot FALSE, trans 4: CL, V1, Q, V2

• ncmt 2, depot TRUE , trans 4: CL, V2, Q, V3, KA

If trans=11 is specified, use the symbols listed above for the ncmt / depot combination, but append i at the end (e.g. CLi or Qi or KAi).

If trans=1, the user must utilize the following symbols:

• pred_CL for clearance

• pred_V or pred_V2 for central compartment volume of distribution

• pred_Q for intercompartmental clearance

• pred_V3 for for peripheral compartment volume of distribution

• pred_KA for absorption rate constant

See Also

BLOCK_PARSE

mrgsolve documentation built on Oct. 18, 2024, 5:12 p.m.