modlib_pkpd: modlib: Pharmacokinetic / pharmacodynamic models
In mrgsolve: Simulate from ODE-Based Models
modlib_pkpd R Documentation
modlib: Pharmacokinetic / pharmacodynamic models
Description
modlib: Pharmacokinetic / pharmacodynamic models
Details
See modlib_details for more detailed descriptions of parameters and
compartments.
All PK/PD models include 2-compartment PK model with absorption from
2 extravascular compartments and linear + nonlinear clearance. The
PK models are parameterized with CL, V2, Q, V3, VMAX, KM, KAandKA2and implement compartmentsEV, EV2, CENT, PERIPH. The indirect response models have compartment RESPand the emax model has output variableRESP. PD parameters include KIN, KOUT, IC50, EC50, IMAX, EMAX, E0, and n'.
Also, once the model is loaded, use the see() method for mrgmod to
view the model code.
Model description
-
irm1: inhibition of response production
-
irm2: inhibition of response loss
-
irm3: stimulation of response production
-
irm4: stimulation of response loss
-
pd_effect: effect compartment model
-
emax: sigmoid emax model
mrgsolve documentation built on May 20, 2026, 9:06 a.m.
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| modlib_pkpd | R Documentation |
modlib: Pharmacokinetic / pharmacodynamic models
Description
modlib: Pharmacokinetic / pharmacodynamic models
Details
See modlib_details for more detailed descriptions of parameters and compartments.
All PK/PD models include 2-compartment PK model with absorption from
2 extravascular compartments and linear + nonlinear clearance. The
PK models are parameterized with CL, V2, Q, V3, VMAX, KM, KAandKA2and implement compartmentsEV, EV2, CENT, PERIPH. The indirect response models have compartment RESPand the emax model has output variableRESP. PD parameters include KIN, KOUT, IC50, EC50, IMAX, EMAX, E0, and n'.
Also, once the model is loaded, use the see() method for mrgmod to
view the model code.
Model description
-
irm1: inhibition of response production -
irm2: inhibition of response loss -
irm3: stimulation of response production -
irm4: stimulation of response loss -
pd_effect: effect compartment model -
emax: sigmoid emax model
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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