posthocControl: Control options for the posthoc estimation method

In nlmixr2est: Nonlinear Mixed Effects Models in Population PK/PD, Estimation Routines

Control options for the posthoc estimation method

Description

This option is for simply getting the maximum a-prior (MAP) also called the posthoc estimates

Usage

posthocControl(sigdig = 3, ..., interaction = FALSE, maxOuterIterations = NULL)

Arguments

sigdig	Optimization significant digits. One value drives, with a single consistent formula, the inner/outer optimizer convergence tolerance (10^-sigdig), the boundary check tolerance (5*10^(-sigdig+1)), and the ODE solver tolerances: the rtol exponent IS sigdig and atol sits three orders below, so rtol = 10^-sigdig, atol = 10^(-sigdig-3) for every solver (stiff, non-stiff or auto-switching). The sensitivity (atolSens/rtolSens) tolerances match the main solve (the outer gradient and covariance are built from them); the steady-state (ssAtol/ssRtol) tolerances run one order looser. Keying the optimizer to the same 10^-sigdig means it converges to exactly the precision the solve supports. At the default sigdig = 3 this is atol = 1e-6, rtol = 1e-3.
...	Parameters used in the default 'foceiConrol()'
interaction	Interaction term for the model, in this case the default is 'FALSE', though you can set it to be 'TRUE' as well.
maxOuterIterations	ignored, posthoc always sets this to 0.

Value

posthocControl object

Author(s)

Matthew L. Fidler

Examples

posthocControl()

nlmixr2est documentation built on Aug. 5, 2026, 1:11 a.m.