Description Usage Arguments Value References

Representing Chen's Design

1 |

`N` |
integer for the total sample size of the trial. |

`mti` |
maximum tolerated imbalance in patient numbers during the trial. |

`p` |
success probability of the biased coin (e.g. in Efron's Biased Coin Design). |

`K` |
number of treatment groups (e.g. K=2 if we compare one experimental against one control treatment). |

A vector with the allocation sequence for a clinical trial.
It will contain a zero (resp. 1) at position `i`

, when patient `i`

is allocated to treatment A (resp. B).

Chen Yung-Pin (1999) Biased coin design with imbalance tolerance. Comm. in Stat., 15, 953-975.

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