shrink.phi: Shrinkaged Estimates of Error Variance

In rmRNAseq: RNA-Seq Analysis for Repeated-Measures Data

Description

This function implements Smyth's approach (empirical bayes estimate of error variance of genes, limma paper 2004).

Usage

shrink.phi(phi.hat, den.df)

Arguments

phi.hat	a numerical vector of the estimated of error variance of all genes.
den.df	denominator degree of freedom associated with the estimated variances phi.hat (=n sample -rank(design)).

Value

a list of 3 components

phi.shrink	vector of shrinkaged estimates of variance.
d0	estimated prior degree of freedom used inthe shrinkage procedure.
phi0	estimated prior variance used in the shrinkage procedure.

Examples

phi.hat <- rchisq(1000, 1)
den.df <- 2
shrinkout <- rmRNAseq:::shrink.phi(phi.hat, den.df)
hist(shrinkout$phi.shrink)

rmRNAseq documentation built on Nov. 8, 2019, 5:06 p.m.