A collection of clinical trial designs and methods, implemented in 'rstan' and R, including: the Continual Reassessment Method by O'Quigley et al. (1990) <doi:10.2307/2531628>; EffTox by Thall & Cook (2004) <doi:10.1111/j.0006341X.2004.00218.x>; the twoparameter logistic method of Neuenschwander, Branson & Sponer (2008) <doi:10.1002/sim.3230>; and the Augmented Binary method by Wason & Seaman (2013) <doi:10.1002/sim.5867>; and more. We provide functions to aid modelfitting and analysis. The 'rstan' implementations may also serve as a cookbook to anyone looking to extend or embellish these models. We hope that this package encourages the use of Bayesian methods in clinical trials. There is a preponderance of early phase trial designs because this is where Bayesian methods are used most. If there is a method you would like implemented, please get in touch.
Package details 


Author  Kristian Brock [aut, cre] (<https://orcid.org/0000000239210166>), Trustees of Columbia University [cph] 
Maintainer  Kristian Brock <kristian.brock@gmail.com> 
License  GPL (>= 3) 
Version  0.1.6 
URL  https://github.com/brockk/trialr 
Package repository  View on CRAN 
Installation 
Install the latest version of this package by entering the following in R:

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