efftox_params-class: Container class for parameters to fit the EffTox model in...

In trialr: Clinical Trial Designs in 'rstan'

Container class for parameters to fit the EffTox model in trialr.

Description

Container class for parameters to fit the EffTox model in trialr.

Usage

efftox_params(
  real_doses,
  efficacy_hurdle,
  toxicity_hurdle,
  p_e,
  p_t,
  eff0,
  tox1,
  eff_star,
  tox_star,
  priors
)

Arguments

real_doses	a vector of numbers.The doses under investigation. They should be ordered from lowest to highest and be in consistent units. E.g., to conduct a dose-finding trial of doses 10mg, 20mg and 50mg, use c(10, 20, 50).
efficacy_hurdle	Minimum acceptable efficacy probability. A number between 0 and 1.
toxicity_hurdle	Maximum acceptable toxicity probability. A number between 0 and 1.
p_e	Certainty required to infer a dose is acceptable with regards to being probably efficacious; a number between 0 and 1.
p_t	Certainty required to infer a dose is acceptable with regards to being probably tolerable; a number between 0 and 1.
eff0	Efficacy probability required when toxicity is impossible; a number between 0 and 1 (see Details).
tox1	Toxicity probability permitted when efficacy is guaranteed; a number between 0 and 1 (see Details).
eff_star	Efficacy probability of an equi-utility third point (see Details).
tox_star	Toxicity probability of an equi-utility third point (see Details).
priors	instance of class efftox_priors, the hyperparameters for normal priors on the six model parameters.

See Also

efftox_priors get_efftox_priors stan_efftox stan_efftox_demo

trialr documentation built on April 1, 2023, 12:03 a.m.