dose_finding_path_node-class: Class to hold the elements of a single dose-finding analysis...

In trialr: Clinical Trial Designs in 'rstan'

Class to hold the elements of a single dose-finding analysis residing in a pathway of analyses.

Description

A pathway in a dose-finding trial is a series of successive analyses. For instance, the model will likely be fit to all of the outcomes observed at the end of the first cohort, the second cohort, etc. This class holds the elements reflecting the analysis, and the place of this analysis in the pathway.

Usage

dose_finding_path_node(
  node_id,
  parent_node_id,
  depth,
  outcomes,
  next_dose,
  fit,
  parent_fit
)

Arguments

node_id	An integer representing the id of this node in a pathway.
parent_node_id	An integer representing the id of this node's parent in the pathway.
depth	An integer representing the depth of this node in the pathway, where the root has depth 0.
outcomes	A string representing the outcomes observed at the time of analysis. See df_parse_outcomes for a description of syntax and examples.
next_dose	An integer representing the dose recommended by the model for the next patient or cohort of patients.
fit	Object obtained from fitting the dose-finding model to outcomes.
parent_fit	Object obtained from fitting the dose-finding model to the outcomes of the parent node. Comparing to fit will oten be valuable.

Value

Instance of class dose_finding_path_node

Examples

## Not run: 
parent_outcomes <- '1NNN'
outcomes <- '1NNN 2NNT'
target <- 0.25
skeleton <- c(0.05, 0.15, 0.25, 0.4, 0.6)
parent_fit <- stan_crm(outcome_str = parent_outcomes, skeleton = skeleton,
                       target = target, model = 'empiric', beta_sd = 1)
fit <- stan_crm(outcome_str = outcomes, skeleton = skeleton,
                target = target, model = 'empiric', beta_sd = 1)
dose_finding_path_node(node_id = 2, parent_node_id = 1, depth = 1,
                       outcomes = outcomes, next_dose = fit$recommended_dose,
                       fit = fit, parent_fit = parent_fit)

## End(Not run)

trialr documentation built on April 1, 2023, 12:03 a.m.