desc_rch: Rechallenge descriptive

In vigicaen: 'VigiBase' Pharmacovigilance Database Toolbox

Rechallenge descriptive

Description

Computes counts of rechallenge cases, over a set of adr and drug pairs.

Usage

desc_rch(.data, drug_s = "drug1", adr_s = "adr1")

Arguments

.data	A link data.table. See link_.
drug_s	A character string. The name of the drug column. Drug columns can be created with add_drug.
adr_s	A character string. The name of the adr column. Adr columns can be created with add_adr.

Details

Counts are provided at the case level (not the drug-adr pair level). Description span from number of rechallenge cases to informative rechallenge cases (those cases where the outcome is known). You will need a link data.table, see link_, on which you have added drugs and adrs with add_drug() and add_adr(). Terminology

• Overall as opposed to rch for rechallenged (rch + no_rch = overall).

• Among rch, inf (informative) as opposed to non_inf (inf + non_inf = rch)

• Among inf, rec (recurring) as opposed to non_rec (rec + non_rec = inf)

Value

A data.table with one row per drug-adr pair

• drug_s and adr_s, same as input.

• Counts of overall, rch, inf, and rec cases (see details).

See Also

link_, add_drug(), add_adr(), desc_dch(), desc_tto()

Examples

link_ <-
  link_ |>
  add_drug(
    d_code = ex_$d_groups_drecno,
    drug_data = drug_
  ) |>
  add_adr(
    a_code = ex_$a_llt,
    adr_data = adr_
  )

desc_rch(.data = link_,
         drug_s = "pd1",
         adr_s = "a_colitis")

# You can vectorize over drugs and adrs

desc_rch(.data = link_,
         adr_s = c("a_colitis", "a_pneumonitis"),
         drug_s = c("pd1", "pdl1")
         )

vigicaen documentation built on April 3, 2025, 8:55 p.m.