BIMSBbioinfo/slimR: Short Linear Motif (SLiM) Analysis in the context of human diseases

slimR is a protein sequence analysis package centered around short linear motifs (SLiMs) and their connections to human diseases. The package contains functions to retrieve data from public databases such as ELM (elm.eu.org), UniProt (uniprot.org). Annotated SLiMs and SLiM patterns (regular expressions) are retrieved from the ELM database. Protein sequence features such as disease-causing mutations, polymorphisms, protein domains, and many other annotated features are retrieved from the UniProt or ClinVar databases. The main motivation of the package is to facilitate analysis of the impact of protein sequence variations due to mutations and polymorphism on the content of SLiMs. Besides functions to retrieve data from public resources, there are functions to calculate disorder scores, search for SLiM instances in given sequences, look for gain/loss of SLiMs due to sequence variations. The package should be useful not only for the analysis of human diseases but also studies of the evolution of species via gain/loss of SLiMs in any comparative context.

install.packages("remotes")
remotes::install_github("BIMSBbioinfo/slimR")