nDom: Variant filtering with dominant inheritance

In BartBroeckx/Mendelian: Variant Analysis for Mendelian Disorders

Description

nDom should be used to filter variants under a dominant mode of inheritance.

Usage

nDom(x, y, family)

Arguments

x	the case(s).
y	optional, the control(s).
family	optional, "P-F" or "Ps-F" mode, indicating a (healthy) parent(s)- (affected) progeny relation.

Details

nDom checks for common variants within cases. If variants from control(s) are present, they can be used to filter variants from the cases. In addition, various detectance and penetrance parameters can be specified during the processing.

If family is specified, penetrance is assumed to be complete. In addition, the causal variant is assumed to be heterozygous in the case.

Author(s)

Bart Broeckx

Examples

output <- nDom("CLCfile1", "CLCfile2"  )
output
output <- nDom(c("CLCfile1","CLCfile2"))
output

BartBroeckx/Mendelian documentation built on May 5, 2019, 10:27 a.m.