Rank_topic_specific: Obtaining the topic-specific ranking list.
In BinDuan/MASCOT: Model-based Analysis of Single cell CRISPR knockOuT screening

Description Usage Arguments Details Value Author(s)

MASCOT prioritizes the gene knockout effect either as an overall perturbation impact on the cells, or in a functional topic-specific way. Here, the function calcultes and obtains the topic-specific ranking list.

1	Rank_topic_specific(rank_overall_result_detail, alpha = 0.5)

`rank_overall_result_detail`	The overall perturbation effect ranking list with the detailed information. It can obtain from "Rank_overall()".
`alpha`	alpha is the weight of impact degree. Its value is between 0 and 1. The default is 0.5 .

For a specific topic, MASCOT prioritizes the perturbation impact by calculating this specific topic probability difference between case and control with the rectifications of overall knockout efficiency and background difference. Intuitively, the ranking list is obtained by evaluating the perturbation effect on this specific topic, where the perturbation should influence this topic as much as possible while keeping other topics as unaffected as possible.

`rank_topic_specific_result_detail`	The topic-specific ranking list with detailed information.
`rank_topic_specific_result_summary`	The topic-specific ranking list with the main information.

Bin Duan

BinDuan/MASCOT documentation built on May 23, 2019, 2:42 p.m.