optGuide: Function optGuide

In CshlSiepelLab/ACE: Analysis of CRISPR Essentiality in R

Description

Given gene and sample parameters, use MLE to obtain guide parameters.

Usage

optGuide(
  guide_features,
  gene_effects,
  sample_effects,
  use_genes,
  write_log,
  user_DataObj,
  user_ModelObj
)

Arguments

guide_features	Weights for guide efficiency features to use on initialization.
gene_effects	By-gene essentiality parameters.
sample_effects	By-sample parameters.
use_genes	Vector of gene names to
write_log	Function to write to central timestamped log file.
user_DataObj	DataObj with experimental data to analyze.
user_ModelObj	ModelObj with preprocessed model parameters.

CshlSiepelLab/ACE documentation built on Sept. 10, 2021, 11:21 p.m.