CoRe.randomisedepMat | R Documentation |
This function takes in input a matrix and shuffles its entries column-wise. Then matrix resulting from this shuffling will have the same column marginal totals of the inputted one.
CoRe.randomisedepMat(depMat)
depMat |
A numeric matrix |
The matrix given in input with entries shuffled column wisely.
C. Pacini, E. Karakoc, A. Vinceti & F. Iorio
[1] Behan FM, Iorio F, Picco G, Gonçalves E, Beaver CM, Migliardi G, et al. Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens. Nature. 2019;568:511–6.
[2] Dwane L, Behan FM, Gonçalves E, Lightfoot H, Yang W, van der Meer D, Shepherd R, Pignatelli M, Iorio F, Garnett MJ. Project Score database: a resource for investigating cancer cell dependencies and prioritizing therapeutic targets. Nucleic Acids Res. 2021 Jan 8;49(D1):D1365-D1372.
## Downloading binary dependency matrix ## for > 300 cancer cell lines from Project Score [1,2] BinDepMat<-CoRe.download_BinaryDepMatrix() ## Extracting dependency submatrix for ## Non-Small Cell Lung Carcinoma cell lines only LungDepMat<-CoRe.extract_tissueType_SubMatrix(BinDepMat) ## Randomising the colums of the submatrix rnd_exampleDepMat<-CoRe.randomisedepMat(LungDepMat)
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