splatEstBCV: Estimate Splat Biological Coefficient of Variation parameters
In Granoia/splatter-mod: Simple Simulation of Single-cell RNA Sequencing Data

Description Usage Arguments Details Value

Parameters are estimated using the estimateDisp function in the edgeR package.

1	splatEstBCV(counts, params)

`counts`	counts matrix to estimate parameters from.
`params`	SplatParams object to store estimated values in.

The estimateDisp function is used to estimate the common dispersion and prior degrees of freedom. See estimateDisp for details. When estimating parameters on simulated data we found a broadly linear relationship between the true underlying common dispersion and the edgR estimate, therefore we apply a small correction, disp = 0.1 + 0.25 * edgeR.disp.

SplatParams object with estimated values.

Granoia/splatter-mod documentation built on May 28, 2019, 12:31 a.m.