splatEstDropout: Estimate Splat dropout parameters
In Granoia/splatter-mod: Simple Simulation of Single-cell RNA Sequencing Data

Description Usage Arguments Details Value

Estimate the midpoint and shape parameters for the logistic function used when simulating dropout.

1	splatEstDropout(norm.counts, params)

`norm.counts`	library size normalised counts matrix.
`params`	SplatParams object to store estimated values in.

Logistic function parameters are estimated by fitting a logistic function to the relationship between log2 mean gene expression and the proportion of zeros in each gene. See nls for details of fitting. Note this is done on the experiment level, more granular (eg. group or cell) level dropout is not estimated.

SplatParams object with estimated values.

Granoia/splatter-mod documentation built on May 28, 2019, 12:31 a.m.