# tests/testthat/test_fstat.R In LieberInstitute/jaffelab: Commonly used functions by the Jaffe lab

```context('F-stats')

set.seed(20161005)
## From limma::limFit example page:
sd <- 0.3 * sqrt(4 / rchisq(100, df = 4))
y <- matrix(rnorm(100 * 6, sd = sd), 100, 6)
rownames(y) <- paste('Gene', seq_len(100))
y[1:2, 4:6] <- y[1:2, 4:6] + 4

## Define the alternative and null models
pheno <- data.frame(group = rep(c(0, 1), each = 3), RIN = runif(6) + 8)
mod <- model.matrix(~ pheno\$group + pheno\$RIN)
mod0 <- model.matrix(~ pheno\$RIN)

## Fit the models
library('limma')
fit <- lmFit(y, mod)
fit0 <- lmFit(y, mod0)

## Calculate the F statistics for these nested models
finfo <- getF(fit, fit0, y)

## Compute F-stats with derfinderHelper to double check
library('derfinderHelper')
fstat <- as.numeric(fstats.apply(data = y, mod = mod, mod0 = mod0, method = 'regular'))
fpval <- pf(fstat, ncol(mod) - ncol(mod0), ncol(y) - ncol(mod), lower.tail = FALSE)

test_that('getF', {
expect_equivalent(finfo\$fstat, fstat)
expect_equivalent(finfo\$f_pval, fpval)
})

## Test getF with vector output from lm()

ctl <- c(4.17,5.58,5.18,6.11,4.50,4.61,5.17,4.53,5.33,5.14)
trt <- c(4.81,4.17,4.41,3.59,5.87,3.83,6.03,4.89,4.32,4.69)
group <- gl(2, 10, 20, labels = c("Ctl","Trt"))
weight <- c(ctl, trt)
lm.fit <- lm(weight ~ group)
lm.fit0 <- lm(weight ~ 1)

test_that('getF with vector', {
expect_equal(getF(lm.fit, lm.fit0, weight)\$f_pval, anova(lm.fit0, lm.fit)[['Pr(>F)']][[2]])
expect_equal(getF(lm.fit, lm.fit0, weight)\$fstat, anova(lm.fit0, lm.fit)[['F']][[2]])
})
```
LieberInstitute/jaffelab documentation built on Aug. 15, 2018, 4:37 a.m.