get_r_from_lor: Estimate proportion of variance of liability explained by SNP...

In MRCIEU/TwoSampleMR: Two Sample MR Functions and Interface to MR Base Database

Estimate proportion of variance of liability explained by SNP in general population

Description

This uses equation 10 in Lee et al. A Better Coefficient of Determination for Genetic Profile Analysis. Genetic Epidemiology 36: 214–224 (2012) \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1002/gepi.21614")}.

Usage

get_r_from_lor(
  lor,
  af,
  ncase,
  ncontrol,
  prevalence,
  model = "logit",
  correction = FALSE
)

Arguments

lor	Vector of Log odds ratio.
af	Vector of allele frequencies.
ncase	Vector of Number of cases.
ncontrol	Vector of Number of controls.
prevalence	Vector of Disease prevalence in the population.
model	Is the effect size estimated from the "logit" (default) or "probit" model.
correction	Scale the estimated r by correction value. The default is FALSE.

Value

Vector of signed r values

MRCIEU/TwoSampleMR documentation built on April 22, 2024, 8:42 p.m.