examples/MinimalInformative.R

In Roche/crmPack: Object-Oriented Implementation of CRM Designs

# Setting up a minimal informative prior 
# max.time is quite small only for the purpose of showing the example. They 
# should be increased for a real case.
set.seed(132)
coarseGrid <- c(0.1, 10, 30, 60, 100)
minInfModel <- MinimalInformative(dosegrid = coarseGrid,
                                  refDose=50,
                                  threshmin=0.2,
                                  threshmax=0.3,
                                  control=## for real case: leave out control 
                                    list(max.time=0.1)) 

# Plotting the result
matplot(x=coarseGrid,
        y=minInfModel$required,
        type="b", pch=19, col="blue", lty=1,
        xlab="dose",
        ylab="prior probability of DLT")
matlines(x=coarseGrid,
         y=minInfModel$quantiles,
         type="b", pch=19, col="red", lty=1)
legend("right",
       legend=c("quantiles", "approximation"),
       col=c("blue", "red"),
       lty=1,
       bty="n")