TransBioInfoLab/coMethDMR: Accurate identification of co-methylated and differentially methylated regions in epigenome-wide association studies

coMethDMR identifies genomic regions associated with continuous phenotypes by optimally leverages covariations among CpGs within predefined genomic regions. Instead of testing all CpGs within a genomic region, coMethDMR carries out an additional step that selects co-methylated sub-regions first without using any outcome information. Next, coMethDMR tests association between methylation within the sub-region and continuous phenotype using a random coefficient mixed effects model, which models both variations between CpG sites within the region and differential methylation simultaneously.

Getting started

Package details

Bioconductor views DNAMethylation DifferentialMethylation Epigenetics GenomeWideAssociation MethylationArray
Package repositoryView on GitHub
Installation Install the latest version of this package by entering the following in R:
TransBioInfoLab/coMethDMR documentation built on April 25, 2022, 1:10 a.m.