library(PopED)
## following example 1.4.2 in PFIM
sfg <- function(x,a,bpop,b,bocc){
## -- parameter definition function
parameters=c(KA=bpop[1]*exp(b[1]),
K=bpop[2]*exp(b[2]),
V=bpop[3]*exp(b[3]),
DOSE=a[1])
return(parameters)
}
ff <- function(model_switch,xt,parameters,poped.db){
##-- Model: One comp first order absorption
with(as.list(parameters),{
y<-(DOSE/V*KA/(KA-K)*(exp(-K*xt)-exp(-KA*xt)))
return(list(y=y,poped.db=poped.db))
})
}
## -- Residual unexplained variablity (RUV) function
## -- Additive + Proportional
feps <- function(model_switch,xt,parameters,epsi,poped.db){
returnArgs <- do.call(poped.db$model$ff_pointer,list(model_switch,xt,parameters,poped.db))
f <- returnArgs[[1]]
y = f + (0.5 + 0.15*f)*epsi[,1]
return(list( y= y,poped.db =poped.db ))
}
## -- Define initial design and design space
poped.db <- create.poped.database(ff_fun=ff,
fg_fun=sfg,
fError_fun =feps,
bpop=c(KA=2, K=0.25, V=15),
d=c(KA=1, V=0.25,0.1),
sigma=c(1),
notfixed_sigma = c(0),
groupsize=1,
xt=c( 1,3,8),
minxt=0,
maxxt=10,
a=100)
(shr_out <- shrinkage(poped.db))
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