scmod1.robust: Subtype Clustering Model using ESR1, ERBB2 and AURKA modules...

In bhklab/genefu: Computation of Gene Expression-Based Signatures in Breast Cancer

Subtype Clustering Model using ESR1, ERBB2 and AURKA modules for identification of breast cancer molecular subtypes (Desmedt et al 2008)

Description

List of parameters defining the Subtype Clustering Model as published in Desmedt et al 2008.

Usage

data(scmod1.robust)

Format

List of parameters for SCMOD1:

• parameters: List of parameters for the mixture of three Gaussians (ER-/HER2-, HER2+ and ER+/HER2-) that define the Subtype Clustering Model. The structure is the same than for an mclust::Mclust() object.

• cutoff.AURKA: Cutoff for AURKA module score in order to identify ER+/HER2- High Proliferation (aka Luminal B) tumors and ER+/HER2- Low Proliferation (aka Luminal A) tumors.

• mod: ESR1, ERBB2 and AURKA modules.

Source

http://clincancerres.aacrjournals.org/content/14/16/5158.abstract?ck=nck

References

Desmedt C, Haibe-Kains B, Wirapati P, Buyse M, Larsimont D, Bontempi G, Delorenzi M, Piccart M, and Sotiriou C (2008) "Biological processes associated with breast cancer clinical outcome depend on the molecular subtypes", Clinical Cancer Research, 14(16):5158–5165.

bhklab/genefu documentation built on Nov. 30, 2024, 9:03 p.m.