scmod2.robust: Subtype Clustering Model using ESR1, ERBB2 and AURKA modules...

In bhklab/genefu: Computation of Gene Expression-Based Signatures in Breast Cancer

Subtype Clustering Model using ESR1, ERBB2 and AURKA modules for identification of breast cancer molecular subtypes (Desmedt et al 2008)

Description

List of parameters defining the Subtype Clustering Model as published in Desmedt et al 2008.

Usage

data(scmod1.robust)

Format

List of parameters for SCMOD2:

• parameters: List of parameters for the mixture of three Gaussians (ER-/HER2-, HER2+ and ER+/HER2-) that define the Subtype Clustering Model. The structure is the same than for an mclust::Mclust object.

• cutoff.AURKA: Cutoff for AURKA module score in order to identify ER+/HER2- High Proliferation (aka Luminal B) tumors and ER+/HER2- Low Proliferation (aka Luminal A) tumors.

• mod: ESR1, ERBB2 and AURKA modules.

Source

http://breast-cancer-research.com/content/10/4/R65k

References

Wirapati P, Sotiriou C, Kunkel S, Farmer P, Pradervand S, Haibe-Kains B, Desmedt C, Ignatiadis M, Sengstag T, Schutz F, Goldstein DR, Piccart MJ and Delorenzi M (2008) "Meta-analysis of Gene-Expression Profiles in Breast Cancer: Toward a Unified Understanding of Breast Cancer Sub-typing and Prognosis Signatures", Breast Cancer Research, 10(4):R65.

bhklab/genefu documentation built on June 2, 2022, 2:56 p.m.