r_kept_fun: Which elements to keep in the optimization procedure?

Description Usage Arguments

Description

This function compares the connection coefficient in the local response matrices when either only free active kinases are measured or when the complexes are switched on. All free parameters a_ij are increased simultaneously

Usage

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r_kept_fun(pars_opt, perturbation_prediction, obs_fun, p_fun, pars,
  alpha = -log(0 + .Machine$double.eps))

Arguments

pars_opt

Free parameters a_ij to control the influence of the complexes

perturbation_prediction

Simulated steady state perturbation data

obs_fun

Observation function which returns the communicating species

p_fun

Parameter transformation which returns different conditions

pars

Parameters of the ODE model

alpha

Compares r(pars_opt) with r(pars_opt + alpha). Since pars_opt_0 defaults to log(0+.Machine$double.eps), I chose its negative value as the default. This is basically the same as comparing r(0) with r(1)


dlill/MRAr documentation built on May 16, 2019, 7:24 a.m.