progress_msm: Disease Progression Module

In dth2/EpiModelHIV_SHAMP: Epidemic Modeling of HIV Transmission among MSM, MSMF and Heterosexual Populations

Description

Module function for HIV disease progression through acute, chronic and AIDS stages.

Usage

progress_msm(dat, at)

Arguments

dat	Master data list object of class dat containing networks, individual-level attributes, and summary statistics.
at	Current time step.

Details

HIV disease is divided into four stages: acute rising, acute falling, chronic and AIDS. Acute rising is the time from infection to peak viremia, while acute falling is the time from peak viremia to chronic stage infection with an established set-point HIV viral load.

The time spent in chronic stage infection, and thus the time from infection to AIDS, depends on ART history. For ART-naive persons, time to AIDS is established by the vl.aids.onset parameter. For persons ever on ART who fall into the partially suppressed category (the tt.traj attribute is 3), time to AIDS depends on the sum of two ratios: time on treatment over maximum time on treatment plus time off treatment over maximum time off treatment. For persons ever on ART who fall into the fully suppressed cateogry (tt.traj=4), time to AIDS depends on whether the cumulative time off treatment exceeds a time threshold specified in the max.time.off.tx.full parameter.

Value

This function returns the dat object after updating the disease stage of infected individuals.

dth2/EpiModelHIV_SHAMP documentation built on May 15, 2019, 4:56 p.m.