plot_signature_pairwise_bleed: Plots pairwise correlations between signatures in MCMC...
In eyzhao/SignIT: What the Package Does (One Line, Title Case)

Description Usage Arguments Details Value

View source: R/plot_signature_pairwise_bleed.R

This plot allows the user to explore their MCMC solutions for the presence of mutation signature bleed effects.

1	plot_signature_pairwise_bleed(exposures_mcmc_output)

exposures_mcmc_output

Output from get_exposures.

The MCMC sample space is likely to contain some degree of multicollinearity. That is to say that some signatures are likely to correlate or anti-correlate with others. This can result from a phenomenon known as "Signature Bleed," wherein signatures may feed into one anothers' signals if they share similar mutational spectra.

This function computes correlation metrics between each pair of signatures. It then plots them as a grid. Signature bleed is associated with anticorrelation between a signature pair, which suggests that good solutions can substitute the contribution of one signature for the other.

A ggplot object showing a heatmap of pairwise correlation coefficients.

eyzhao/SignIT documentation built on Dec. 6, 2019, 11:45 a.m.