nnls_exposures: Calculate signature exposures

In eyzhao/hrdtools: Homologous Recombination Deficiency Tests with Whole Genome Sequencing

Description

This function determines the signature exposures using non-negative least squares.

Usage

nnls_exposures(subjectMotifs, refSignature, fractions = FALSE,
  montecarlo = FALSE, iterations = 2000)

Arguments

subjectMotifs	The mutation catalog of a subject derived from mutation_catalog()
refSignature	The reference signature table, which can be imported by get_reference_signatures()
fractions	If TRUE, will return results as a fraction of all mutations rather than number of mutations.
montecarlo	If TRUE, will perform Monte Carlo simulation to obtain 95 percent confidence limits
iterations	The number of iterations of Monte Carlo to run

eyzhao/hrdtools documentation built on May 21, 2019, 3:09 a.m.