Description Usage Arguments Value
View source: R/viper-helpers.R
The procedure applies the Maslov-Sneppen procedure, i.e. substitutes regulatory protein targets with the same number of randomly assigned targets, thus producing a random program topology while preserving the number of target genes of each RP.
1 | randomize_regulon(regulon, universe = NULL, seed = 42)
|
regulon |
regulon object - see output of viper::aracne2regulon |
universe |
set to NULL, can be supplied to provide the gene universe to chose targets from |
seed |
before random sampling |
regulon with randomized targets and preserved topology
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