randomize_regulon: Generate a randomized network

Description Usage Arguments Value

View source: R/viper-helpers.R

Description

The procedure applies the Maslov-Sneppen procedure, i.e. substitutes regulatory protein targets with the same number of randomly assigned targets, thus producing a random program topology while preserving the number of target genes of each RP.

Usage

1
randomize_regulon(regulon, universe = NULL, seed = 42)

Arguments

regulon

regulon object - see output of viper::aracne2regulon

universe

set to NULL, can be supplied to provide the gene universe to chose targets from

seed

before random sampling

Value

regulon with randomized targets and preserved topology


fossbert/binilib documentation built on April 23, 2021, 10:31 p.m.