postprocess_depvalue: Compute the negative log-10 p-values across all cell types

In linnykos/multiomicCCA: Tilted CCA

Compute the negative log-10 p-values across all cell types

Description

This function does the following: There are varible cell types stored in de_list$level_vec. For each cell type, enumerate the p-value (across different features, i.e., genes or proteins) when comparing that cell type against all other cell types. Return the p-value at the quantile of quantile_value among all these comparisons for this particular cell type. Then, repeat for all cell types, resulting in a p-value for each cell type and each feature. Lastly, for each feature, take the maximum of the -log10 p-value (across all the cell types).

Usage

postprocess_depvalue(
  de_list,
  exclude_celltypes = NULL,
  maximum_output = NULL,
  quantile_value = 0.75,
  verbose = 1
)

Arguments

de_list	output of the tiltedCCA::differential_expression function
exclude_celltypes	a vector of strings containing cell types to be excluded in this function's calculations. All the cell types should be in de_list$level_vec
maximum_output	any output (i.e., negative log10 pvalue) larger than maximum_output are set to be maximum_output
quantile_value	for a particular variable, when comparing one cell type to all other cell types, output the p-value at the quantile of quantile_value . (prior to taking the maximum of the -log10 across all cell types)
verbose	non-negative integer

Value

a vector of the -log10 p-value for each variable in de_list

linnykos/multiomicCCA documentation built on July 17, 2025, 3:16 a.m.