Group_specific_Var_Delta_AUC_estimation: Variance of the Difference of AUC of Two Group-Specific...

In marie-alexandre/AUCtest: Statistical test - Between group comparison of AUC

Description

\loadmathjax

This function calculates the variance of the difference of area under the curve of two marginal dynamics modeled by group-structured polynomials or B-spline curve in Mixed-Effects models.

Usage

Group_specific_Var_Delta_AUC_estimation(
  MEM_Pol_group,
  Group1,
  Group2,
  time.G1,
  time.G2,
  method = "trapezoid",
  Group.dependence = TRUE,
  Averaged = FALSE
)

Arguments

MEM_Pol_group	A list with similar structure than the output provided by the function MEM_Polynomial_Group_structure. A list containing: Model_estimation either the variance-covariance matrix of the marginal (fixed) parameters (at least for Group1 and Group2), or a list containing at least this matrix labeled 'varFix' (see MEM_Polynomial_Group_structure for details about the parameter order). Model_features a list of at least 2 elements: 1. Groups - a vector indicating the names of the groups whose variance of fixed parameters are given. 2. Marginal.dyn.feature - a list summarizing the features of the marginal dynamics defined in the model: dynamic.type - a character scalar indicating the chosen type of marginal dynamics. Options are 'polynomial' or 'spline' intercept - a logical vector summarizing choices about global and group-specific intercepts (Number of groups + 1) elements whose elements are named as ('global.intercept','group.intercept1', ..., 'group.interceptG') if G Groups are defined in MEM_Pol_group. For each element of the vector, if TRUE, the considered intercept is considered as included in the model. If dynamic.type is defined as 'polynomial': polynomial.degree - an integer vector indicating the degree of polynomial functions, one value for each group. If dynamic.type is defined as 'spline': spline.degree - an integer vector indicating the degree of B-spline curves, one for each group. knots - a list of group-specific internal knots used to build B-spline basis (one numerical vector for each group) (see bs for more details). df - a numerical vector of group-specific degrees of freedom used to build B-spline basis, (one for each group). boundary.knots - a list of group-specific boundary knots used to build B-spline basis (one vector for each group) (see bs for more details).
Group1	a character scalar indicating the name of the first group whose marginal dynamics must be considered. This group name must belong to the set of groups involved in the MEM (see Groups vector in MEM_Pol_group).
Group2	a character scalar indicating the name of the second group whose marginal dynamics must be considered. This group name must belong to the set of groups involved in the MEM (see Groups vector in MEM_Pol_group).
time.G1	a numerical vector of time points (x-axis coordinates) to use for the variance of the Group1 AUC calculation (AUC and its variance use the same time points).
time.G2	a numerical vector of time points (x-axis coordinates) to use for the variance of the Group2 AUC calculation (AUC and its variance use the same time points).
method	a character scalar indicating the interpolation method to use to estimate the AUC. Options are 'trapezoid' (default), 'lagrange' and 'spline'. In this verion, the 'spline' interpolation is implemented with "not-a-knot" spline boundary conditions.
Group.dependence	a logical scalar indicating whether the two groups, whose the difference of AUC (\mjseqn\Delta \textAUC) is studied, are considered as dependent. By default, this variable is defined as TRUE.
Averaged	a logical scalar. If TRUE, the function return the difference of normalized AUC (nAUC) where nAUC is computated as the AUC divided by the range of time of calculation. If FALSE (default), the classic AUC is calculated.

Value

A numerical scalar corresponding to the variance of the difference of AUC (\mjseqn\Delta \textAUC) between the Group1 and the Group2. If the two groups are considered as dependent (Group.dependence=TRUE), the variance of \mjseqn\Delta \textAUC is calculated as \mjseqn\textVar(\textAUC_1) + \textVar(\textAUC_2) - 2\textCov(\textAUC_1,\textAUC_2). Otherwise, only the sum of the two variance is used.

See Also

bs, Group_specific_Var_AUC_estimation, MEM_Polynomial_Group_structure

Examples

# Download of data
data("HIV_Simu_Dataset_Delta01_cens")
data <- HIV_Simu_Dataset_Delta01_cens

# Change factors in character vectors
data$id <- as.character(data$id) ; data$Group <- as.character(data$Group)

# Example 1: We consider the variable \code{MEM_Pol_Group} as the output of our function \link[AUCtest]{MEM_Polynomial_Group_structure}
MEM_estimation <- MEM_Polynomial_Group_structure(y=data$VL,x=data$time,Group=data$Group,Id=data$id,Cens=data$cens)
Var_Delta_AUC_estimation <- Group_specific_Var_Delta_AUC_estimation(MEM_Pol_group=MEM_estimation,Group1="Group1",Group2="Group2",
                                                                    time.G1=unique(data$time[which(data$Group=="Group1")]),
                                                                    time.G2=unique(data$time[which(data$Group=="Group2")]))
                                                                    
Example 2: We consider results of MEM estimation from another source. We have to give build the variable 'MEM_Pol_group' with the good structure
 # We build the variable 'MEM_Pol_group.1' with the results of MEM estimation obtained for two groups 
Covariance_Matrix_1 <- matrix(rnorm(7*7,mean=0,sd=0.01),ncol=7,nrow=7) # Generation of random matrix
Covariance_Matrix_1 <- Covariance_Matrix_1 %*% t(Covariance_Matrix_1) # Transform the matrix into symmetric one
MEM_Pol_group.1 <- list(Model_estimation=Covariance_Matrix_1, # Covariance matrix of fixed effects for all parameters
                       Model_features=list(Groups=c("Group1","Group2"),
                                           Marginal.dyn.feature=list(dynamic.type="polynomial",intercept=c(global.intercept=TRUE,group.intercept1=FALSE,group.intercept2=FALSE),polynomial.degree=c(3,3))))
                                           
Var_Delta_AUC_estimation_2 <- Group_specific_Var_Delta_AUC_estimation(MEM_Pol_group=MEM_Pol_group.1,Group1="Group1",Group2="Group2",
                                                                    time.G1=unique(data$time[which(data$Group=="Group1")]),
                                                                    time.G2=unique(data$time[which(data$Group=="Group2")]))

marie-alexandre/AUCtest documentation built on Jan. 1, 2021, 8:31 a.m.