fitHSA_ray: fit HSA and Bliss model given a fixed ratio design with input...

In nickytong/drexplorer: Dose-response Explorer

Description

fit HSA and Bliss model given a fixed ratio design with input (d1, d2, e)

Usage

fitHSA_ray(d1, d2, e, tol = 0.05, strict = TRUE, name1 = "Drug A",
  name2 = "Drug B", dmin = NULL, dmax = NULL, islogd = TRUE,
  bootstrapB = 0, nrep = 3, seed = 100)

Arguments

d1	drug 1 dose in original scale
e	response at the dose pair
strict	whether to stop if not fixed ratio; this is just for visualization; the calculations of synergy is wrong since d12=d1+d2 is meaningless for variable ratio! At the end, this is a waste of time: it would not make sense and impossible to do this!
dmin	start position to calcualte AUC at projected dose, in original scale, default is minimum projected dose
dmax	end position to calcualte AUC at projected dose, in original scale, default is maximum projected dose
islogd	whether to compute AUC at log10 dose; if TRUE, dmin and dmax must also be log10 scale
d1	drug 2 dose in original scale

nickytong/drexplorer documentation built on May 23, 2019, 5:08 p.m.