fit_median_efect: fit median-effect model for 2-drug combination with a fixed...

Description Usage Arguments Value

Description

notice that the median-effect model is a special case of the sigma Emax model; 3 linear models are fitted; fixed ratio thus is required. all 3 linear models are fitted using logit(E) ~ log(d1+d2) using a subset of the data depending on if the data is for durg 1, drug 2 and the mixture

Usage

1
2
fit_median_efect(d1, d2, e, name1 = "Drug A", name2 = "Drug B", d2.d1,
  base = exp(1))

Arguments

d1

dose for drug 1

d2

dose for drug 2

e

corresponding response in the range [0, 1]

name1

drug 1 name

name2

drug 2 name

d2.d1

d2/d1, the fixed ratio

base

base of logarithm; disabled since the dose-response curve estimation also needs transformation

Value

a list


nickytong/drexplorer documentation built on May 23, 2019, 5:08 p.m.