Description Usage Arguments Details Value
this function scaled the response by mean reponse in control when necessary
1 |
drMat |
dose-response matrix as for drFit. the first column being dosage and second column being response. controls are included by specifying dose=0 |
alpha |
a scalar for significance level. This specifies the significance level to identify outliers which will be excluded from model fitting. To include all data, set alpha=1. |
fitCtr |
A logic vector specifying whether to include the control points into the model fitting. |
standardize |
whether to standardize (scale) the data based on control points. This should be disabled when no control data is supplied |
the standardization means response (e.g. count) is to be scaled by mean control response so that the standardized response is relative viability, usually between 0 and 1. this function first detects outlier data points (using supplied data, either scaled or not scaled). It then scale the data and split the data into two data frames: one for dose not 0 and one for dose at 0 Ideally, outlier detection is better at original count (or signal intensity) due to asymptotic assumption But for data already scaled, detection outlier at this level is what we can do
a list
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