new_regimen: Dose regimen for sim_ode
In ronkeizer/PKPDsim: Simulate ODE models

Description Usage Arguments Value See Also Examples

Create a dosing regimen for use with sim_ode

new_regimen(amt = 100, interval = NULL, n = 3, times = NULL,
  type = NULL, t_inf = NULL, rate = NULL, t_lag = NULL, cmt = NULL,
  checks = TRUE, ss = FALSE, n_ss = NULL,
  first_dose_time = lubridate::now())

`amt`	dosing amount, either a single value (which will repeated for multiple doses), or a vector with doses for each administration
`interval`	dosing interval (requires n as argument)
`n`	number of doses (requires interval as argument)
`times`	vector describing dosing times. Overrides specified times using interval and n arguments
`type`	either "infusion" or "bolus" (default)
`t_inf`	infusion time (if 'type'=='infusion')
`rate`	infusion rate (if 'type'=='infusion'). 'NULL' by default. If specified, overrides 't_inf'
`t_lag`	lag time (can be applied to any dose type, not only oral). Will just be added to 'times'
`cmt`	vector of dosing compartments (optional, if NULL will dosing compartment defined in model will be used)
`checks`	input checks. Remove to increase speed (e.g. for population-level estimation or optimal design)
`ss`	steady state? boolean value whether to simulate out to steady state first (steady state will be based on specified 'amt' and 'interval', 'times' will be ignored).
`n_ss`	how many doses to simulate before assumed steady state. Default is 4 * 24 / 'interval'.
`first_dose_time`	datetime stamp of first dose (of class 'POSIXct'). Default is current date time.

a list containing calculated VPC information, and a ggplot2 object

sim_ode

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r1 <- new_regimen(amt=50, interval=12, n=20) # dose 50mg, q12hrs for 10 days
r2 <- new_regimen(amt=50, times=c(0:19)*12)  # same, but using explicit times
r3 <- new_regimen(amt=c(rep(100,4), rep(50,16)), times=c(0:19)*12)  # first 4 doses higher dose