pk_1cmt_oral: Concentration predictions for 1-compartmental oral PK model...

In ronkeizer/clinPK: Clinical Pharmacokinetics Toolkit

Description

Concentration predictions for 1-compartmental oral PK model after single or multiple bolus doses

Usage

pk_1cmt_oral(t = c(0:24), dose = 100, tau = 12, KA = 1, CL = 3,
  V = 30, F = 1, ruv = NULL)

Arguments

t	vector of time
dose	dose
tau	dosing interval
KA	absorption rate
CL	clearance
V	volume of distribution
F	bioavailability, commonly between 0 an 1.
ruv	residual error (list)

References

Garrett ER. The Bateman function revisited: a critical reevaluation of the quantitative expressions to characterize concentrations in the one compartment body model as a function of time with first-order invasion and first-order elimination. J Pharmacokinet Biopharm (1994) 22(2):103-128.

Bialer M. A simple method for determining whether absorption and elimination rate constants are equal in the one-compartment open model with first-order processes. J Pharmacokinet Biopharm (1980) 8(1):111-113

Nielsen JC, Hutmacher MM et al. J Pharmacokinet Pharmacodyn. 2012 Dec;39(6):619-34. doi: 10.1007/s10928-012-9274-0. Epub 2012 Sep 23.

https://static-content.springer.com/esm/art

Examples

pk_1cmt_oral(dose = 500, tau = 12, CL = 5, V = 50, KA = 1)

ronkeizer/clinPK documentation built on May 20, 2019, 5:07 p.m.