pk_2cmt_inf_dose_from_cmax: Calculate dose to achieve steady state Cmax for...

In ronkeizer/clinPK: Clinical Pharmacokinetics Toolkit

Description

Calculate dose to achieve steady state Cmax for 2-compartmental PK model with infusion dosing at steady state

Usage

pk_2cmt_inf_dose_from_cmax(cmax = 1, tau = 12, t_inf = 1, CL = 3,
  V = 30, Q = 2, V2 = 20)

Arguments

cmax	desired trough concentration
tau	dosing interval
t_inf	infusion time
CL	clearance
V	volume of distribution
Q	inter-compartimental clearance
V2	volume of peripheral compartment

Examples

dos <- pk_2cmt_inf_dose_from_cmax(
  cmax = 25, tau = 12, t_inf = 2,
  CL = 5, V = 50, Q = 20, V2 = 200)
find_nearest_dose(dos, 100)

ronkeizer/clinPK documentation built on May 20, 2019, 5:07 p.m.