Description Usage Arguments Value Examples
compute b0, projection matrix, given methylation counts
1 | getb0.biseq(methmat, design, sigg = NULL)
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methmat |
a matrix of counts with rows corresponding to methylation sites and columns. Columns are: chr start end strand coverage1 numCs1 numTs1 coverage2 numCs2 numTs2 .... |
design |
design matrix, output of model.matrix |
sigg |
predetermined signature CpG sites. Format sites as chromosome name, chromosome location, strand: chrN_position(+/-). For example, chr1_906825- |
b0 projection matrix. Coefficients are beta.
1 2 3 4 5 | ## Not run:
data("data_celltypes_rrbs")
b0.rrbs = getb0.biseq(methmat, design.rrbs, sigg=NULL)
## End(Not run)
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