toy_network: Toy Input Network

In saezlab/COSMOS: COSMOS (Causal Oriented Search of Multi-Omic Space)

Toy Input Network

Description

This signaling network is the reduced COSMOS network solution obtained in the cosmos test on 786-O NCI60 data. Here, this network solution is reused as an exemplary input prior knowledge network (PKN).

Usage

data(toy_network)

Format

An object of class “data.frame” with 19 rows (interactions) and three variables:

source

Source node, either metabolite or protein

interaction

Type of interaction, 1 = Activation, -1 = Inhibition

target

Target node, either metabolite or protein

A detailed description of the identifier formatting can be found under https://metapkn.omnipathdb.org/00__README.txt.

Source

The network data are available on github: https://github.com/saezlab/COSMOS_MSB/tree/main/results/COSMOS_result/COSMOS_res_session.RData. The toy_network is the combined network of the COSMOS network solutions CARNIVAL_Result2 and CARNIVAL_Result_rerun subsequently reduced to 19 exemplary nodes.

References

Dugourd, A., Kuppe, C. and Sciacovelli, M. et. al. (2021) Molecular Systems Biology. 17, e9730.

Examples

data(toy_network)

saezlab/COSMOS documentation built on July 24, 2024, 7:37 p.m.